{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T04:58:54Z","timestamp":1771736334208,"version":"3.50.1"},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0022215125102946_sec1a\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The present review aims at an insight into the pathophysiology of chronic rhinosinusitis with nasal polyposis through the combination of three tissue sources: (1) nasal polyp, (2) neighboring non-polypoid mucosa (MS) and (3) healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215125102946_sec2b\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The primary outcomes included three lists of molecules (1) those significantly different between nasal polyp, neighboring non-polypoid mucosa and controls (2) those up\/downregulated in nasal polyp, but comparable between MS and controls and (3) those comparable between nasal polyp and neighboring non-polypoid mucosa, but different between NP and controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215125102946_sec3c\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ten studies investigating a large variety of 68 molecules presented comparisons between nasal polyp and neighboring non-polypoid mucosa in endotype-specified populations. Comparisons between nasal polyp and neighboring non-polypoid mucosa are approached separately for eosinophilic\/non-eosinophilic chronic rhinosinusitis with nasal polyposis . The small number of studies prohibits a meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215125102946_sec4d\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Inclusion of neighboring non-polypoid mucosa in future studies may provide a bias-free list of the molecules that contribute to the actual pathogenesis and preservation of nasal polyps within the chronic rhinosinusitis inflammatory environment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0022215125102946","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T05:34:41Z","timestamp":1753853681000},"page":"1015-1020","source":"Crossref","is-referenced-by-count":0,"title":["Molecular differences in the nasal microenvironment of chronic rhinosinusitis with nasal polyposis: a systematic 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