{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:03:09Z","timestamp":1779667389761,"version":"3.53.1"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0022215125103538_sec1a\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Clinical trials provide valuable treatment insights but often fail to represent real-world outcomes. This is particularly true for advanced laryngeal cancer patients, who face significant co-morbidities and socioeconomic challenges. This study evaluates whether outcomes from research datasets in The Cancer Imaging Archive reflect real-world survival in a regional cohort from North-East England.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215125103538_sec2b\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective analysis compares outcomes between The Cancer Imaging Archive (n = 198) and North-East England (n = 222) cohorts. Demographics, treatment modalities and five-year disease-specific survival were assessed via Kaplan\u2013Meier curves and Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215125103538_sec3c\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      North-East England had a lower five-year disease-specific survival (59.2 per cent vs. 76.9 per cent;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0018) and was characterised by greater co-morbidity burden and upfront surgery with adjuvant therapy (51 per cent), whereas The Cancer Imaging Archive patients received upfront chemoradiotherapy (53 per cent) or radiotherapy alone (41 per cent).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215125103538_sec4d\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The poorer real-world outcomes reflect the challenges of generalising research data to heterogeneous populations. Bridging the gap between research efficacy and real-world effectiveness is critical to delivering equitable care for advanced laryngeal cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0022215125103538","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:05:25Z","timestamp":1759730725000},"page":"31-36","source":"Crossref","is-referenced-by-count":0,"title":["When research data meet reality: contrasting advanced laryngeal cancer outcomes in The Cancer Imaging Archive (TCIA) and a United Kingdom regional cohort"],"prefix":"10.1017","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9323-3107","authenticated-orcid":false,"given":"Amar","family":"Rajgor","sequence":"first","affiliation":[{"name":"Newcastle University"},{"name":"National Institute for Health Research, Newcastle University"},{"name":"Newcastle-Upon-Tyne Hospitals NHS Foundation Trust, Freeman Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Kui","sequence":"additional","affiliation":[{"name":"Newcastle-Upon-Tyne Hospitals NHS Foundation Trust, Freeman Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aileen","family":"Mill","sequence":"additional","affiliation":[{"name":"Newcastle University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Rushton","sequence":"additional","affiliation":[{"name":"Newcastle University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boguslaw","family":"Obara","sequence":"additional","affiliation":[{"name":"Newcastle University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Winston","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Newcastle University"},{"name":"Newcastle-Upon-Tyne Hospitals NHS Foundation Trust, Freeman Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"S0022215125103538_ref16","unstructured":"16 Munford, L , Bambra, C , Davies, H , Pickett, K , Taylor-Robinson, D. Health Equity North 2023. Newcastle upon Tyne. In: https:\/\/www.healthequitynorth.co.uk\/app\/uploads\/2023\/04\/HEN-REPORT.pdf [ 1 September 2025 ]"},{"key":"S0022215125103538_ref6","doi-asserted-by":"publisher","DOI":"10.1186\/1916-0216-43-4"},{"key":"S0022215125103538_ref26","article-title":"Head-and-neck squamous cell carcinoma patients with CT taken during pre-treatment, mid-treatment, and post-treatment (HNSCC-3DCT-RT) [Data set]","author":"Bejarano","year":"2018","journal-title":"The Cancer Imaging Archive"},{"key":"S0022215125103538_ref7","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1671"},{"key":"S0022215125103538_ref22","article-title":"HNSCC Version 4 [Data set]","author":"Grossberg","year":"2020","journal-title":"The Cancer Imaging Archive"},{"key":"S0022215125103538_ref28","unstructured":"28 MHRA. MHRA guideline on randomised controlled trials using real-world data to support regulatory decisions. In: https:\/\/www.gov.uk\/government\/publications\/mhra-guidance-on-the-use-of-real-world-data-in-clinical-studies-to-support-regulatory-decisions\/mhra-guideline-on-randomised-controlled-trials-using-real-world-data-to-support-regulatory-decisions#types-of-rwd-trials-and-points-to-consider 2021 [19 March 2025 ]"},{"key":"S0022215125103538_ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-017-1870-2"},{"key":"S0022215125103538_ref1","unstructured":"1 Head and Neck Cancers Statistics. Cancer Research UK. 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Cancer Data Hub, National Disease Registration Service. In: https:\/\/digital.nhs.uk\/ndrs\/data\/data-outputs\/cancer-data-hub [1 April 2024]"},{"key":"S0022215125103538_ref18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10371-5"},{"key":"S0022215125103538_ref2","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1017\/S002221512400032X","article-title":"Head and neck cancer: United Kingdom National Multidisciplinary Guidelines, Sixth Edition","volume":"138","author":"Homer","year":"2024","journal-title":"J Laryngol Otol"},{"key":"S0022215125103538_ref5","doi-asserted-by":"publisher","DOI":"10.1038\/s41415-022-5151-4"},{"key":"S0022215125103538_ref17","first-page":"93","article-title":"AJCC Cancer Staging Manual. 8th ed. New York: Springer; 2017. (Or, if you prefer the overview article: Amin MB, et al","volume":"67","author":"Amin","year":"2017","journal-title":"CA Cancer J Clin"},{"key":"S0022215125103538_ref3","unstructured":"3 Survival for laryngeal cancer. 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