{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T11:54:28Z","timestamp":1772452468709,"version":"3.50.1"},"reference-count":12,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0022215125104040_sec1a\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to describe a one-stage technique for nasal skin defect reconstruction using an oxidised regenerated cellulose\/collagen matrix (Promogran\u2122) to enhance contour and graft survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215125104040_sec2b\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Following excision of a skin lesion, Promogran\u2122 is cut to size, placed in the wound bed to restore contour and provide bulk, saturated with blood and covered with a full-thickness skin graft.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215125104040_sec3c\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The technique improves cosmesis and enables graft survival over avascular structures, including exposed bone and cartilage. Promogran\u2122 exerts wound-healing effects such as matrix metalloprotease inhibition, regulation of growth factors and cytokines, free-radical scavenging and fibroblast proliferation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215125104040_sec4d\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This simple, one-stage approach offers an alternative to complex or multistage reconstruction for patients unsuitable\u00a0for, or preferring to avoid, more invasive procedures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0022215125104040","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T09:17:16Z","timestamp":1765963036000},"page":"225-229","source":"Crossref","is-referenced-by-count":0,"title":["Contour improvements in skin graft reconstruction of nasal defects"],"prefix":"10.1017","volume":"140","author":[{"given":"Neil David","family":"McNiven","sequence":"first","affiliation":[{"name":"University Hospitals Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4537-8368","authenticated-orcid":false,"given":"Jemma","family":"Butler","sequence":"additional","affiliation":[{"name":"Worcestershire Acute Hospitals"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahram","family":"Anari","sequence":"additional","affiliation":[{"name":"University Hospitals Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"S0022215125104040_ref6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.2002.10703.x"},{"key":"S0022215125104040_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(02)00062-6"},{"key":"S0022215125104040_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(02)00054-7"},{"key":"S0022215125104040_ref7","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2004.13.6.26628"},{"key":"S0022215125104040_ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2005.130316.x"},{"key":"S0022215125104040_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2005.31831"},{"key":"S0022215125104040_ref8","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2004.13.Sup1.2"},{"key":"S0022215125104040_ref5","volume-title":"StatPearls","author":"Ramsey","year":"2023"},{"key":"S0022215125104040_ref2","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2002.34979"},{"key":"S0022215125104040_ref3","volume-title":"Scott-Brown\u2019s Otorhinolaryngology, Head and Neck Surgery","volume":"3","author":"Kok","year":"2018"},{"key":"S0022215125104040_ref10","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-200206000-00017"},{"key":"S0022215125104040_ref1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12021"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215125104040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T10:57:22Z","timestamp":1772449042000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215125104040\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,17]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S0022215125104040"],"URL":"https:\/\/doi.org\/10.1017\/s0022215125104040","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,17]]}}}