{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T18:55:25Z","timestamp":1793818525214,"version":"4.6.1"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0022215125104076_sec1a\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate the diagnostic and surveillance performance of circulating tumour human papillomavirus DNA for post-treatment monitoring of human papilloma virus\u2013positive oropharyngeal squamous cell carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215125104076_sec2b\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Systematic review and meta-analysis of prospective studies (2019\u20132024) identified from PubMed, Web of Science and Scopus. Random-effects models were used to pool circulating tumour human papillomavirus DNA detectability and summarise lead-times to recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215125104076_sec3c\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifteen studies (n=1,447) were included; 10 cohorts (n=731) entered the quantitative meta-analysis. Pooled baseline detectability was 85.5 per cent (95 per cent confidence interval 78.2\u201390.6). Circulating tumour human papillomavirus DNA positivity preceded clinical recurrence by a mean of 76.8 days (median 87.5). Specificity and negative predictive value were consistently high, whereas sensitivity varied by assay platform and sampling frequency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215125104076_sec4d\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serial circulating tumour human papilloma virus DNA testing is a reliable adjunct to post-treatment surveillance in HPV-positive oropharyngeal squamous cell carcinoma, offering a clinically meaningful lead-time to recurrence. Standardised assays and multicentre validation are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0022215125104076","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T06:11:25Z","timestamp":1765433485000},"page":"123-131","source":"Crossref","is-referenced-by-count":2,"title":["Beyond the conventional: the efficacy of liquid biopsy in post-therapeutic monitoring of oropharyngeal cancer, a meta-analysis"],"prefix":"10.1017","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6799-5351","authenticated-orcid":false,"given":"Sabina","family":"Dranova","sequence":"first","affiliation":[{"name":"Frimley Park Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"key":"S0022215125104076_ref23","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33798"},{"key":"S0022215125104076_ref12","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy251"},{"key":"S0022215125104076_ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-025-05898-3"},{"key":"S0022215125104076_ref24","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32804"},{"key":"S0022215125104076_ref8","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-0211"},{"key":"S0022215125104076_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2022.03.232"},{"key":"S0022215125104076_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.12.019"},{"key":"S0022215125104076_ref18","first-page":"1","article-title":"Human papilloma virus circulating tumor DNA assay predicts treatment response in recurrent or metastatic head and neck squamous cell carcinoma","volume":"27","author":"Haring","year":"2021","journal-title":"Clin Cancer Res"},{"key":"S0022215125104076_ref21","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-63180-8"},{"key":"S0022215125104076_ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2023.1730"},{"key":"S0022215125104076_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2022.09.016"},{"key":"S0022215125104076_ref5","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10071525"},{"key":"S0022215125104076_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-023-07952-8"},{"key":"S0022215125104076_ref10","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13206039"},{"key":"S0022215125104076_ref20","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25368"},{"key":"S0022215125104076_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30759"},{"key":"S0022215125104076_ref14","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27866"},{"key":"S0022215125104076_ref16","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.6191"},{"key":"S0022215125104076_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.05.061"},{"key":"S0022215125104076_ref13","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-2338"},{"key":"S0022215125104076_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2023.109773"},{"key":"S0022215125104076_ref22","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-0293"},{"key":"S0022215125104076_ref6","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-22-0562"},{"key":"S0022215125104076_ref1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02444"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215125104076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T10:57:07Z","timestamp":1772449027000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215125104076\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,11]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S0022215125104076"],"URL":"https:\/\/doi.org\/10.1017\/s0022215125104076","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,11]]}}}