{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T08:16:53Z","timestamp":1778141813662,"version":"3.51.4"},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0022215125104258_sec1a\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the efficacy of intranasal cryotherapy to treat chronic rhinitis refractory to medical therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215125104258_sec2b\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      An evaluation was performed for all patients (\n                      <jats:italic>n<\/jats:italic>\n                      = 36) with chronic rhinitis refractory to medical treatment who underwent intranasal cryotherapy between 2022 and 2024 at this centre. The primary outcome measures were changes in validated pre- and post-operative scoring systems (Total Nasal Symptom Score, Sino-Nasal Outcome Test 22 (SNOT-22), Nasal Obstruction Symptom Evaluation and peak inspiratory nasal flow).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215125104258_sec3c\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Objective scoring pre- and post-procedure showed statistically significant improvement across all measures (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001): mean Total Nasal Symptom Score (12 hours) 8.4 to 5.3, Total Nasal Symptom Score (2 weeks) 9.2 to 5.9, SNOT-22 56 to 31, Nasal Obstruction Symptom Evaluation 57.5 to 28.5 and peak inspiratory nasal flow 98 to 138 l\/min.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215125104258_sec4d\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the only dataset for patients receiving intranasal cryotherapy in the UK to date and follows patients over a two-year period. The results support the ongoing use of intranasal cryotherapy for sustained treatment of refractory chronic rhinitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0022215125104258","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T07:58:34Z","timestamp":1767945514000},"page":"396-402","source":"Crossref","is-referenced-by-count":0,"title":["Intranasal cryotherapy for refractory chronic rhinitis: a prospective study"],"prefix":"10.1017","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9431-1082","authenticated-orcid":false,"given":"Charlotte","family":"Arnold","sequence":"first","affiliation":[{"name":"Swansea Bay University Health Board"},{"name":"Imperial College London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5264-5076","authenticated-orcid":false,"given":"Simon","family":"Morris","sequence":"additional","affiliation":[{"name":"Swansea Bay University Health Board"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Owen","family":"Bodger","sequence":"additional","affiliation":[{"name":"Swansea University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heikki","family":"Whittet","sequence":"additional","affiliation":[{"name":"Swansea Bay University Health Board"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"S0022215125104258_ref3","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4141"},{"key":"S0022215125104258_ref4","doi-asserted-by":"publisher","DOI":"10.29337\/ijsp.160"},{"key":"S0022215125104258_ref13","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820986581"},{"key":"S0022215125104258_ref16","unstructured":"16 British National Formulary. 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In: https:\/\/www.nice.org.uk\/guidance\/ipg771\/evidence\/overview-final-pdf-13135019581 [5 April 2025]"},{"key":"S0022215125104258_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.02.031"},{"key":"S0022215125104258_ref10","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21991"},{"key":"S0022215125104258_ref14","doi-asserted-by":"publisher","DOI":"10.1177\/19458924231152331"},{"key":"S0022215125104258_ref15","doi-asserted-by":"publisher","DOI":"10.18787\/jr.2024.00015"},{"key":"S0022215125104258_ref1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00013904"},{"key":"S0022215125104258_ref2","unstructured":"2 National Institute for Health and Care Excellence. Clinical Knowledge Summaries: Allergic Rhinitis 2024. 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