{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:06:50Z","timestamp":1792087610691,"version":"4.4.0"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0022215126104320_sec1a\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate the clinical efficacy and potential immunomodulatory effects of autologous platelet concentrates in promoting tissue regeneration and enhancing post-operative recovery in otorhinolaryngology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126104320_sec2b\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search of PubMed, Scopus and the Cochrane Library was conducted through November 2025, focusing on randomised controlled trials and prospective studies using autologous platelet concentrates in otological, rhinological and laryngological surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126104320_sec3c\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twelve studies met the inclusion criteria. Autologous platelet concentrates improved tissue healing, most notably by increasing graft uptake rates in myringoplasty. Recent trials (2024\u20132025) also reported reduced post-operative pain and mucosal oedema following tonsillectomy and tympanoplasty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126104320_sec4d\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Autologous platelet concentrates appear to be effective adjuncts for enhancing regeneration and reducing post-operative morbidity in ear, nose, and throat procedures. These benefits likely involve downregulation of pro-inflammatory cytokines (e.g., interleukin-6) and modulation of matrix metalloproteinases (e.g., matrix metalloproteinase-9). Standardised biomarker-based studies are needed to confirm these mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0022215126104320","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T12:06:50Z","timestamp":1768219610000},"page":"346-352","source":"Crossref","is-referenced-by-count":2,"title":["Enhancing wound healing in otorhinolaryngology with autologous platelet concentrates: a systematic review of clinical outcomes"],"prefix":"10.1017","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8610-065X","authenticated-orcid":false,"given":"Rizki Ekaputra","family":"Handoko","sequence":"first","affiliation":[{"name":"Universitas Brawijaya"},{"name":"Universitas Brawijaya\/Dr. Saiful Anwar General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loeki Enggar","family":"Fitri","sequence":"additional","affiliation":[{"name":"Universitas Brawijaya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirta Hediyati","family":"Reksodiputro","sequence":"additional","affiliation":[{"name":"Universitas Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhelya","family":"Widasmara","sequence":"additional","affiliation":[{"name":"Universitas Brawijaya\/Dr. Saiful Anwar General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"S0022215126104320_ref6","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.1303"},{"key":"S0022215126104320_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2021.103010"},{"key":"S0022215126104320_ref1","doi-asserted-by":"publisher","DOI":"10.1186\/s43163-022-00325-8"},{"key":"S0022215126104320_ref17","doi-asserted-by":"publisher","DOI":"10.1186\/scrt218"},{"key":"S0022215126104320_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2022.103755"},{"key":"S0022215126104320_ref14","doi-asserted-by":"publisher","DOI":"10.33545\/26646455.2023.v5.i2a.25"},{"key":"S0022215126104320_ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s43163-021-00190-x"},{"key":"S0022215126104320_ref11","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1055\/s-0040-1717083","article-title":"Platelet-rich fibrin enhances surgical wound healing in total laryngectomy","volume":"37","author":"Reksodiputro","year":"2021","journal-title":"Facial Plast Surg"},{"key":"S0022215126104320_ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-024-08824-5"},{"key":"S0022215126104320_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejenta.2012.03.003"},{"key":"S0022215126104320_ref4","doi-asserted-by":"publisher","DOI":"10.3390\/jpm15060233"},{"key":"S0022215126104320_ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-025-09530-6"},{"key":"S0022215126104320_ref18","doi-asserted-by":"publisher","DOI":"10.1080\/08977190802636713"},{"key":"S0022215126104320_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2024.10.005"},{"key":"S0022215126104320_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-024-06128-w"},{"key":"S0022215126104320_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.988"},{"key":"S0022215126104320_ref9","first-page":"e53202","article-title":"The impact of topical application of platelet-rich fibrin on graft survival in surgeries for chronic otitis media","volume":"16","author":"Saini","year":"2024","journal-title":"Cureus"},{"key":"S0022215126104320_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.advms.2024.09.004"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215126104320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T08:04:55Z","timestamp":1778141095000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215126104320\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,12]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S0022215126104320"],"URL":"https:\/\/doi.org\/10.1017\/s0022215126104320","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,12]]}}}