{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:53:58Z","timestamp":1785912838329,"version":"3.56.0"},"reference-count":46,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0022215126104538_sec1a\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma (OPSCC) exhibits a favourable prognosis compared to non-HPV OPCSCC. Tumour infiltrating lymphocytes (TILs) may predict better survival outcomes for patients with HPV+OPSCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126104538_sec2b\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective review of patients treated for HPV+OPSCC between 2003-2018. TIL density scores for each patient\u2019s tumour specimen were determined. Patients were categorised as TIL-Hi or TIL-Lo. Survival outcomes for the two TIL groups were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126104538_sec3c\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty-seven patients, 33 in the TIL-Hi group, were included. 5-year overall survival was 81.8% in the TIL-Hi and 75% in the TIL-Lo groups. 5-year disease specific survival was 87.9% and 87.5%, respectively. There was no statistically significant difference in survival outcomes between TIL-Hi and TIL-Lo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126104538_sec4d\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TIL density in HPV+OPSCC has been reported to predict survival outcomes. This is not supported by the findings of this study. Further prospective evaluation with a standardised scoring technique may fully elicit the prognostic value of TILs in HPV+OPSCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0022215126104538","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:26:41Z","timestamp":1772173601000},"page":"495-500","source":"Crossref","is-referenced-by-count":1,"title":["Tumour-infiltrating lymphocytes do not predict survival in human papillomavirus-associated oropharyngeal squamous cell carcinoma: a single institution retrospective review"],"prefix":"10.1017","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7949-4194","authenticated-orcid":false,"given":"Michael","family":"Fitzsimons","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01hxy9878","id-type":"ROR","asserted-by":"publisher"}],"name":"Royal College of Surgeons in 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