{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:54:08Z","timestamp":1785412448435,"version":"3.56.0"},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0022215126104599_sec1a\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (SCC) has favourable oncological outcomes, supporting the use of transoral robotic surgery with risk-adapted adjuvant therapy. While anticipated adjuvant treatment intensity is informed by pre-operative assessment, definitive post-operative histopathology determines final risk stratification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126104599_sec2b\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single-centre study was conducted at University College London Hospitals of 44 HPV-positive oropharyngeal SCC patients treated with primary transoral robotic surgery and selective neck dissection. Discrepancies between clinical and pathological staging, and their impact on adjuvant treatment recommendations, were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126104599_sec3c\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Staging discrepancies were identified in 38 per cent of patients. Pathological nodal upstaging occurred in 20.5 per cent of patients, commonly caused by higher-than-anticipated nodal burden. Involved surgical margins were present in 70.5 per cent of patients. Overall, definitive histopathology resulted in escalation of anticipated adjuvant treatment intensity in 61 per cent of patients, with 52 per cent reclassified as high-risk disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126104599_sec4d\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Post-operative histopathology frequently altered anticipated risk stratification, highlighting the limitations of pre-operative staging and the clinical impact of a surgical-first approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0022215126104599","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T03:19:42Z","timestamp":1774322382000},"page":"675-679","source":"Crossref","is-referenced-by-count":0,"title":["Transoral robotic surgery for human papillomavirus-positive oropharyngeal squamous cell carcinoma: a retrospective observational study from a UK tertiary centre"],"prefix":"10.1017","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5831-8355","authenticated-orcid":false,"given":"Rebecca Yerin","family":"Im","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02jx3x895","id-type":"ROR","asserted-by":"publisher"}],"name":"University College London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conrad","family":"Orori","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/042fqyp44","id-type":"ROR","asserted-by":"publisher"}],"name":"University College London Hospitals NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8849-7581","authenticated-orcid":false,"given":"Jonathan","family":"Hughes","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/042fqyp44","id-type":"ROR","asserted-by":"publisher"}],"name":"University College London Hospitals NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Stimpson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/042fqyp44","id-type":"ROR","asserted-by":"publisher"}],"name":"University College London Hospitals NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"S0022215126104599_ref19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032646"},{"key":"S0022215126104599_ref20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032641"},{"key":"S0022215126104599_ref1","unstructured":"1 Schiff, AB. Oropharyngeal squamous cell carcinoma. MSD Manual Professional Edition 2024. In: https:\/\/www.msdmanuals.com\/professional\/ear-nose-and-throat-disorders\/tumors-of-the-head-and-neck\/oropharyngeal-squamous-cell-carcinoma [2 November 2025]"},{"key":"S0022215126104599_ref12","volume-title":"TNM classification of malignant tumours","author":"Brierley","year":"2017"},{"key":"S0022215126104599_ref10","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-198212000-00014"},{"key":"S0022215126104599_ref17","first-page":"1111","article-title":"Measuring institutional quality in head and neck surgery using hospital-level data: negative margin rates and neck dissection yield","volume":"143","author":"Schoppy","year":"2017","journal-title":"Otolaryngol Head Neck Surg"},{"key":"S0022215126104599_ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"S0022215126104599_ref4","first-page":"193","article-title":"Cancer risk associated with alcohol and tobacco use: focus on upper aero-digestive tract and liver. alcohol research and health","volume":"29","author":"Pelucchi","year":"2006","journal-title":"Alcohol Res Health"},{"key":"S0022215126104599_ref5","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0551"},{"key":"S0022215126104599_ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-024-01929-1"},{"key":"S0022215126104599_ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1598-x"},{"key":"S0022215126104599_ref13","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13769"},{"key":"S0022215126104599_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2012.02.009"},{"key":"S0022215126104599_ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s11701-024-01910-0"},{"key":"S0022215126104599_ref16","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30204"},{"key":"S0022215126104599_ref14","first-page":"1043","article-title":"Oncologic outcomes after transoral robotic surgery: a multi-institutional study","volume":"141","author":"De Almeida","year":"2015","journal-title":"Otolaryngol Head Neck Surg"},{"key":"S0022215126104599_ref23","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12092474"},{"key":"S0022215126104599_ref2","first-page":"1","article-title":"Oropharyngeal cancer treatment (adult): patient version","year":"2025","journal-title":"PDQ Cancer Information Summaries"},{"key":"S0022215126104599_ref11","unstructured":"11 Royal College of Pathologists. Standards and datasets for reporting cancers 2023. In: https:\/\/www.rcpath.org\/static\/c4a9faf7-393a-4ba8-9532f719d8cdff3b\/7b0a5709-ce18-4694-8e4c84a4ffd466f2\/Dataset-for-histopathology-reporting-of-carcinomas-of-the-oral-cavity.pdf [10 February 2026]"},{"key":"S0022215126104599_ref8","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116000505"},{"key":"S0022215126104599_ref21","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4372"},{"key":"S0022215126104599_ref3","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-0633"},{"key":"S0022215126104599_ref15","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23294"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215126104599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T07:01:34Z","timestamp":1784271694000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215126104599\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,24]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0022215126104599"],"URL":"https:\/\/doi.org\/10.1017\/s0022215126104599","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,24]]}}}