{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:53:55Z","timestamp":1785912835503,"version":"3.56.0"},"reference-count":12,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0022215126104666_sec1a\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Total ossicular replacement prostheses are commonly used to restore hearing in the conductive hearing impaired. However, total ossicular replacement prostheses are expensive and scarcely available in low- and middle-income countries. Therefore, the aim was to develop and validate an open-source design of a total ossicular replacement prosthesis that can be produced locally for low- and middle-income countries hospitals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126104666_sec2b\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Based on input from literature and clinicians a design was made and verified. Accuracy, re-bending safety, cadaver ear fitting, sound transmission and production learning curves were tested.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126104666_sec3c\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A titanium sheet metal total ossicular replacement prosthesis, costing 9 euro, showed accurate dimensions, surgeons showed short learning curves, and sound transmission was similar to commercial total ossicular replacement prostheses. Re-bending tests demonstrated bending corrections could be safely done. Good cadaver ear fitting could be demonstrated, without conflicts between the titanium sheet metal total ossicular replacement prosthesis and anatomical features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126104666_sec4d\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The titanium sheet metal total ossicular replacement prosthesis design has proved to be feasible for implementation in low- and middle-income countries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0022215126104666","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T10:46:04Z","timestamp":1774867564000},"page":"563-570","source":"Crossref","is-referenced-by-count":1,"title":["Design and technical validation of a low-cost, titanium sheet metal TORP (SM-T) for manufacturing and use in LMICs"],"prefix":"10.1017","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3610-0877","authenticated-orcid":false,"given":"Arjan J.","family":"Knulst","sequence":"first","affiliation":[{"name":"International Nepal Fellowship"},{"id":[{"id":"https:\/\/ror.org\/02e2c7k09","id-type":"ROR","asserted-by":"publisher"}],"name":"Delft University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"van Asperen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02e2c7k09","id-type":"ROR","asserted-by":"publisher"}],"name":"Delft University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabin Raj","family":"Gautam","sequence":"additional","affiliation":[{"name":"International Nepal Fellowship"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Geerts","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02e2c7k09","id-type":"ROR","asserted-by":"publisher"}],"name":"Delft University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"ten Have","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02e2c7k09","id-type":"ROR","asserted-by":"publisher"}],"name":"Delft University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Hou","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02e2c7k09","id-type":"ROR","asserted-by":"publisher"}],"name":"Delft University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Neuman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02e2c7k09","id-type":"ROR","asserted-by":"publisher"}],"name":"Delft University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Smith","sequence":"additional","affiliation":[{"name":"International Nepal Fellowship"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Dankelman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02e2c7k09","id-type":"ROR","asserted-by":"publisher"}],"name":"Delft University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"S0022215126104666_ref8","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13101476"},{"key":"S0022215126104666_ref4","doi-asserted-by":"publisher","DOI":"10.3109\/00016486209126959"},{"key":"S0022215126104666_ref11","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215126105167"},{"key":"S0022215126104666_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2021.110658"},{"key":"S0022215126104666_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050123"},{"key":"S0022215126104666_ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2388-1"},{"key":"S0022215126104666_ref1","unstructured":"1 WHO. Deafness and Hearing Loss - fact sheet. In: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/deafness-and-hearing-loss [28 October 2025]"},{"key":"S0022215126104666_ref9","unstructured":"9 ten Have, G . Design of an Affordable Total Ossicular Reconstruction Prosthesis(TORP). In: https:\/\/repository.tudelft.nl\/record\/uuid:975cb939-15e7-4918-b39c-43c5cb24b1b1 [28 October 2025]"},{"key":"S0022215126104666_ref6","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002847"},{"key":"S0022215126104666_ref7","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2011.556662"},{"key":"S0022215126104666_ref10","unstructured":"10 Hou, S. Affordable Design of Total Ossicular Replacement Prostheses in Low- and Middle-Income Countries. In: https:\/\/repository.tudelft.nl\/record\/uuid:6bbbf2db-5b4b-43d0-a964-19d235dd21c5 [28 October 2025]"},{"key":"S0022215126104666_ref2","doi-asserted-by":"publisher","DOI":"10.3389\/fresc.2024.1491473"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215126104666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:37:59Z","timestamp":1785911879000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215126104666\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,30]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S0022215126104666"],"URL":"https:\/\/doi.org\/10.1017\/s0022215126104666","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,30]]}}}