{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T11:35:54Z","timestamp":1786448154577,"version":"build-2736575974"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0022215126104885_sec1a\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Juvenile nasopharyngeal angiofibroma is a highly vascular benign tumour affecting adolescent males. Our aim was to compare operative outcomes in embolised and non-embolised patients, with emphasis on tumour stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126104885_sec2b\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review was conducted using three databases (PubMed, Scopus and Google Scholar) in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126104885_sec3c\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 17 studies with a total of 524 patients met the inclusion criteria. The meta-analysis showed a significant difference in estimated blood loss between embolised and non-embolised groups (overall effect size -685 ml;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Additionally, embolised patients with advanced stage tumours tended to lose less blood during surgery than non-embolised patients (mean of 1551.9 ml vs. 4051.5 ml;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.065).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126104885_sec4d\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This systematic review and meta-analysis demonstrate that pre-operative endovascular embolisation provides an operative advantage in patients undergoing juvenile nasopharyngeal angiofibroma surgical resection. A near-significant trend towards greater benefit in higher-stage tumours was observed (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.065), warranting further prospective investigation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0022215126104885","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:01:32Z","timestamp":1778054492000},"page":"718-725","source":"Crossref","is-referenced-by-count":0,"title":["Operative benefits of embolisation in advanced-stage juvenile nasopharyngeal angiofibroma: a meta-analytic comparison"],"prefix":"10.1017","volume":"140","author":[{"given":"Aviv Yvonne","family":"Segal","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03kgsv495","id-type":"ROR","asserted-by":"publisher"}],"name":"Bar-Ilan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basem","family":"Hijazi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03kgsv495","id-type":"ROR","asserted-by":"publisher"}],"name":"Bar-Ilan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7084-0695","authenticated-orcid":false,"given":"Ohad","family":"Ronen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03kgsv495","id-type":"ROR","asserted-by":"publisher"}],"name":"Bar-Ilan University"},{"id":[{"id":"https:\/\/ror.org\/000ke5995","id-type":"ROR","asserted-by":"publisher"}],"name":"Galilee Medical Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"S0022215126104885_ref4","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.185908"},{"key":"S0022215126104885_ref22","first-page":"348","article-title":"Perioperative management of juvenile nasopharyngeal angiofibroma: a retrospective analysis of 56 patients from a single tertiary care institute","volume":"84","author":"Punj","year":"2016","journal-title":"AANA J"},{"key":"S0022215126104885_ref13","doi-asserted-by":"publisher","DOI":"10.1177\/000348947508400603"},{"key":"S0022215126104885_ref14","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.133.4.657"},{"key":"S0022215126104885_ref12","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10173926"},{"key":"S0022215126104885_ref6","doi-asserted-by":"publisher","DOI":"10.1017\/S002221510012359X"},{"key":"S0022215126104885_ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2010.83"},{"key":"S0022215126104885_ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-017-1587-3"},{"key":"S0022215126104885_ref30","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.303"},{"key":"S0022215126104885_ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050092"},{"key":"S0022215126104885_ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-05276-6"},{"key":"S0022215126104885_ref2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24696"},{"key":"S0022215126104885_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2009.04.007"},{"key":"S0022215126104885_ref19","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215109992726"},{"key":"S0022215126104885_ref20","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1314087"},{"key":"S0022215126104885_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000568"},{"key":"S0022215126104885_ref29","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30616"},{"key":"S0022215126104885_ref5","doi-asserted-by":"publisher","DOI":"10.1177\/014556131509400615"},{"key":"S0022215126104885_ref24","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215118001779"},{"key":"S0022215126104885_ref26","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2020.4253"},{"key":"S0022215126104885_ref21","first-page":"337","article-title":"A study on role of preoperative embolisation in surgery of juvenile nasopharyngeal angiofibroma and its outcome","volume":"3","author":"Banjara","year":"2015","journal-title":"Int J Res Heal Sci"},{"key":"S0022215126104885_ref9","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197208000-00015"},{"key":"S0022215126104885_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2010.11.011"},{"key":"S0022215126104885_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/BF00204142"},{"key":"S0022215126104885_ref15","doi-asserted-by":"publisher","DOI":"10.1080\/00016480252775814"},{"key":"S0022215126104885_ref16","first-page":"68","article-title":"Surgical management of juvenile nasopharyngeal angiofibroma, with and without pre-operative embolization. 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