{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T11:35:56Z","timestamp":1786448156160,"version":"build-2736575974"},"reference-count":37,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0022215126104976_sec1a\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare subjective and psychophysical olfactory outcomes in patients with eosinophilic chronic rhinosinusitis controlled after primary functional endoscopic sinus surgery (FESS) alone versus those treated with dupilumab for post-operative recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126104976_sec2b\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort study included 357 adults undergoing primary FESS. Patients were classified into a FESS group (disease controlled after surgery alone,\n                      <jats:italic>n<\/jats:italic>\n                      = 334) and a dupilumab group (post-operative recurrence treated with dupilumab without revision surgery,\n                      <jats:italic>n<\/jats:italic>\n                      = 23). Subjective olfaction was assessed using the self-administered odour questionnaire and psychophysical function was assessed using standardised olfactory threshold testing. Pre- and post-treatment outcomes were compared within and between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126104976_sec3c\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Baseline age, sex, asthma prevalence and psychophysical thresholds did not differ significantly. The Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis scores, blood eosinophils and self-administered odour questionnaire scores were worse in the dupilumab group at baseline. Both groups showed significant improvement after treatment, with no significant differences in post-treatment outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126104976_sec4d\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dupilumab for post-operative recurrence achieved olfactory improvement comparable to primary FESS alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0022215126104976","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T09:52:04Z","timestamp":1780307524000},"page":"756-763","source":"Crossref","is-referenced-by-count":0,"title":["Olfactory outcomes after primary endoscopic sinus surgery and dupilumab for post-operative recurrence in eosinophilic chronic rhinosinusitis"],"prefix":"10.1017","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3796-5346","authenticated-orcid":false,"given":"Takahiro","family":"Saito","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/001yc7927","id-type":"ROR","asserted-by":"publisher"}],"name":"Hyogo Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Hirose","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/001yc7927","id-type":"ROR","asserted-by":"publisher"}],"name":"Hyogo Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takenori","family":"Haruna","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/001yc7927","id-type":"ROR","asserted-by":"publisher"}],"name":"Hyogo Medical 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