{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T11:36:09Z","timestamp":1786448169158,"version":"build-2736575974"},"reference-count":11,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2026,7]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n This study aimed to evaluate the clinical applications, observed haemostatic outcomes of a self-assembling peptide haemostat (PuraBond\u00ae) across a range of ENT surgical procedures using a large UK observational registry.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A two-cycle observational study of 600 patients at University Hospitals Birmingham NHS Foundation Trust (September 2019\u2013July 2024). Data collected included patient demographics, comorbidities, anticoagulation status, surgical details, intra-operative haemostatic outcomes and post-operative complications.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Intra-operative haemostasis was documented without the need for additional haemostatic intervention in 99.8% of cases (599\/600). Immediate haemostasis-related complication rate was 0.2% (1\/600). The overall complication rate was 3% per cent, with most complications unrelated to haemostasis or the use of PuraBond. The study limitations include participant heterogeneity, absence of a control group and small subspeciality sample sizes underscoring the need for comparative studies.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This registry demonstrates PuraBond\u2019s broad applicability in ENT surgery as an adjunct to routine haemostats and provides essential groundwork for designing future comparative trials.<\/jats:p>\n <\/jats:sec>","DOI":"10.1017\/s0022215126104988","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T09:52:04Z","timestamp":1780307524000},"page":"793-799","source":"Crossref","is-referenced-by-count":0,"title":["Clinical utility of self-assembling peptide haemostat (PuraBond\u00ae) in ENT surgery: a 600-patient observational registry at University Hospitals Birmingham"],"prefix":"10.1017","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6510-6365","authenticated-orcid":false,"given":"Asiya Kamber","family":"Zaidi","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/014ja3n03","id-type":"ROR","asserted-by":"publisher"}],"name":"University Hospitals Birmingham NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi Tabitha","family":"Mohanarajah","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/014ja3n03","id-type":"ROR","asserted-by":"publisher"}],"name":"University Hospitals Birmingham NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Consultants at UHB for Research & Excellence in ENT (CURE ENT Collaborative Group)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahzada K","family":"Ahmed","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/014ja3n03","id-type":"ROR","asserted-by":"publisher"}],"name":"University Hospitals Birmingham NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"S0022215126104988_ref5","doi-asserted-by":"publisher","DOI":"10.1177\/26348535231171332"},{"key":"S0022215126104988_ref7","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.10.1271"},{"key":"S0022215126104988_ref6","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.679525"},{"key":"S0022215126104988_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-022-07312-y"},{"key":"S0022215126104988_ref11","first-page":"104302","article-title":"Evaluating the role of the self-assembling topical haemostat PuraBond\u00ae in transoral robotic surgery for oropharyngeal cancer: a case series","volume":"80","author":"Gupta","year":"2022","journal-title":"Ann Med Surg (Lond)"},{"key":"S0022215126104988_ref1","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znad361"},{"key":"S0022215126104988_ref10","doi-asserted-by":"publisher","DOI":"10.2310\/7070.2004.02084"},{"key":"S0022215126104988_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.sdentj.2022.11.007"},{"key":"S0022215126104988_ref2","doi-asserted-by":"publisher","DOI":"10.1177\/08839115221147935"},{"key":"S0022215126104988_ref3","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15051534"},{"key":"S0022215126104988_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2017.09.001"}],"container-title":["The Journal of Laryngology & Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215126104988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T11:07:17Z","timestamp":1786446437000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215126104988\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":11,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0022215126104988"],"URL":"https:\/\/doi.org\/10.1017\/s0022215126104988","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,1]]}}}