{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:23:12Z","timestamp":1793406192987,"version":"4.5.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0022215126105313_sec1a\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Gross tumour volume has been proposed as a complementary prognostic marker in laryngeal squamous cell carcinoma. This systematic review and meta-analysis evaluates the prognostic value of pre-treatment gross tumour volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126105313_sec2b\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MEDLINE, Embase and Scopus were systematically searched according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies reporting pre-treatment gross tumour volume and survival outcomes in laryngeal cancer were included. The primary outcome was overall survival, and the secondary outcome was disease-free survival. Hazard ratios were pooled using random-effects meta-analysis. Risk of bias was assessed using the Quality in Prognosis Studies tool, and certainty of evidence using the Grading of Recommendations Assessment, Development and Evaluation approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126105313_sec3c\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight retrospective studies including 1351 patients were included. Increasing gross tumour volume was significantly associated with worse overall survival (pooled hazard ratio per 1 cm\n                      <jats:sup>3<\/jats:sup>\n                      increase: 1.03; 95 per cent confidence interval: 1.02\u20131.05), with a similar association observed for disease-free survival. Overall risk of bias was moderate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126105313_sec4d\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher gross tumour volume is independently associated with poorer survival in laryngeal cancer and may provide prognostic information beyond tumour-node-metastasis staging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0022215126105313","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T08:11:44Z","timestamp":1782979904000},"page":"935-945","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic value of gross tumour volume in laryngeal cancer: a systematic review and meta-analysis"],"prefix":"10.1017","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5119-3576","authenticated-orcid":false,"given":"Shahid","family":"Iqbal","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0168r3w48","id-type":"ROR","asserted-by":"publisher"}],"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Illahi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02fyj2e56","id-type":"ROR","asserted-by":"publisher"}],"name":"Calderdale and Huddersfield NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumail","family":"Zaheer","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00tejnf65","id-type":"ROR","asserted-by":"publisher"}],"name":"Macquarie University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashir","family":"Iqbal","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0220mzb33","id-type":"ROR","asserted-by":"publisher"}],"name":"King's College London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ely Cheikh","family":"Boussaty","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0168r3w48","id-type":"ROR","asserted-by":"publisher"}],"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles S.","family":"Coffey","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0168r3w48","id-type":"ROR","asserted-by":"publisher"}],"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,7,2]]},"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215126105313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:00:55Z","timestamp":1790953255000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215126105313\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,2]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0022215126105313"],"URL":"https:\/\/doi.org\/10.1017\/s0022215126105313","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,2]]}}}