{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:53:43Z","timestamp":1790956423066,"version":"4.1.0"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0022215126105374_sec1a\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate the association between the severity of nasal obstruction and carotid intima\u2013media thickness in patients with nasal septal deviation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126105374_sec2b\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study included 60 patients scheduled for septoplasty and 50 age-, sex- and body mass index\u2013matched healthy controls. Correlation analyses and receiver operating characteristics curve analyses were performed to determine associations and optimal cutoff values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126105374_sec3c\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both right (0.62 \u00b1 0.12 mm) and left (0.63 \u00b1 0.12 mm) common carotid artery intima\u2013media thickness values were significantly higher in the nasal septal deviation group compared to controls (0.51 \u00b1 0.09 mm and 0.51 \u00b1 0.07 mm, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Receiver operating characteristics analyses revealed that Visual Analogue Scale greater than or equal to 7.5 (sensitivity 85.7 per cent; specificity 67.4 per cent) and Nasal Obstruction Symptom Evaluation greater than or equal to 72.5 (sensitivity 92.9per cen; specificity 65.1 per cent) reliably predicted elevated carotid intima\u2013media thickness (&gt;0.7 mm).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126105374_sec4d\" sec-type=\"conclusions\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Nasal septal deviation\u2013related nasal obstruction was significantly associated with increased carotid intima\u2013media thickness, suggesting a possible contribution to cardiovascular risk. Larger multicenter studies are warranted to validate these findings. The Australian New Zealand CTN: ACTRN12619000347167<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0022215126105374","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:40:20Z","timestamp":1783575620000},"page":"981-987","source":"Crossref","is-referenced-by-count":0,"title":["Impact of nasal obstruction severity on carotid intima\u2013media thickness in patients with nasal septal deviation"],"prefix":"10.1017","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7643-7100","authenticated-orcid":false,"given":"B\u00fclent","family":"Ulusoy","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04gx7mb59","id-type":"ROR","asserted-by":"publisher"}],"name":"Sel\u00e7uk University Faculty of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Tun\u00e7ez","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04gx7mb59","id-type":"ROR","asserted-by":"publisher"}],"name":"Sel\u00e7uk University Faculty of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"G\u00fcl","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03xe1kn47","id-type":"ROR","asserted-by":"publisher"}],"name":"Konya Beyhekim Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muslu Kaz\u0131m","family":"K\u00f6rez","sequence":"additional","affiliation":[{"name":"Sel\u00e7uk University Faculty of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcseyin","family":"Tezcan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04gx7mb59","id-type":"ROR","asserted-by":"publisher"}],"name":"Sel\u00e7uk University Faculty of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6mer","family":"Erdur","sequence":"additional","affiliation":[{"name":"Sel\u00e7uk University Faculty of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"S0022215126105374_ref20","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000008027"},{"key":"S0022215126105374_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000004955"},{"key":"S0022215126105374_ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-016-1371-7"},{"key":"S0022215126105374_ref9","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9879463"},{"key":"S0022215126105374_ref2","first-page":"e31317","article-title":"Nasal septal deviation: a comprehensive narrative review","volume":"14","author":"Alghamdi","year":"2022","journal-title":"Cureus"},{"key":"S0022215126105374_ref5","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000003814"},{"key":"S0022215126105374_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.artres.2017.04.007"},{"key":"S0022215126105374_ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-4042-1"},{"key":"S0022215126105374_ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000343145"},{"key":"S0022215126105374_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2013.07.013"},{"key":"S0022215126105374_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s40119-022-00261-x"},{"key":"S0022215126105374_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2006.05.004"},{"key":"S0022215126105374_ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-015-0066-7"},{"key":"S0022215126105374_ref18","first-page":"839582","article-title":"Patients with obstructive sleep apnea display increased carotid intima media: a meta-analysis","volume":"2013","author":"Nadeem","year":"2013","journal-title":"Int J Vasc Med"},{"key":"S0022215126105374_ref6","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.027657"},{"key":"S0022215126105374_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2020.102671"},{"key":"S0022215126105374_ref10","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.046361"},{"key":"S0022215126105374_ref11","doi-asserted-by":"publisher","DOI":"10.3906\/sag-1509-81"},{"key":"S0022215126105374_ref1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30684"},{"key":"S0022215126105374_ref19","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-2223"},{"key":"S0022215126105374_ref8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.628875"}],"container-title":["The Journal of Laryngology &amp; 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