{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:04:46Z","timestamp":1789635886413,"version":"4.0.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n This study aimed to assess pre- and post-radiation therapy mandibular bone densities in head and neck cancer patients with osteoradionecrosis and factors associated with decreased bone densities.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Retrospective pilot study (2007\u20132017) of osteoradionecrosis patients after 66- to 70-gray radiation therapy. Cortical and cancellous mandibular bone densities ipsilateral\/contralateral to tumour were measured on pre-radiation therapy and at three-month and one-year post-radiation therapy positron emission tomography\/computed tomography. Two-way analysis of variance and linear regression were used as exploratory analyses, given the pilot nature of the study.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Sixteen of 67 head and neck cancer patients had osteoradionecrosis (41\u201367 years of age; nine African Americans, seven Caucasians). Bone density did not significantly change from baseline within either racial group. African Americans had higher bone densities than Caucasians (pre-radiation therapy ipsilateral cortical: 1044 \u00b1 229.8 vs. 965.6\u00b1 278.7 Hounsfield units). At one year, African Americans had higher contralateral cortical (+35.5 per cent;\n p<\/jats:italic>\n = 0.008) and cancellous (+109.4 per cent;\n p<\/jats:italic>\n = 0.028) bone densities. Multivariable models showed lower contralateral cortical (\n p<\/jats:italic>\n = 0.039) and cancellous (\n p<\/jats:italic>\n = 0.005) bone densities in Caucasians.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In this small pilot study, mandibular bone densities appeared higher in African Americans, with a greater post-radiation therapy reduction observed in Caucasians; these findings are exploratory and require validation in larger cohorts.<\/jats:p>\n <\/jats:sec>","DOI":"10.1017\/s0022215126105532","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:14:18Z","timestamp":1784013258000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Racial differences in bone density variation in head and neck cancer patients with osteoradionecrosis: A pilot study"],"prefix":"10.1017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6998-1658","authenticated-orcid":false,"given":"Srivatsa Surya","family":"Vasudevan","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03151rh82","id-type":"ROR","asserted-by":"publisher"}],"name":"Louisiana State University Health Sciences Center Shreveport"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijit","family":"Gundale","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Florida College of Medicine - Jacksonville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Mijalis","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/044pcn091","id-type":"ROR","asserted-by":"publisher"}],"name":"The University of Mississippi Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amol","family":"Takalkar","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05dm4ck87","id-type":"ROR","asserted-by":"publisher"}],"name":"Emory University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent","family":"Burton","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03151rh82","id-type":"ROR","asserted-by":"publisher"}],"name":"Louisiana State University Health Sciences Center Shreveport"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Moore-Medlin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03151rh82","id-type":"ROR","asserted-by":"publisher"}],"name":"Louisiana State University Health Sciences Center Shreveport"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"McLarty","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03151rh82","id-type":"ROR","asserted-by":"publisher"}],"name":"Feist-Weiller Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cherie-Ann O.","family":"Nathan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03151rh82","id-type":"ROR","asserted-by":"publisher"}],"name":"Louisiana State University Health Sciences Center Shreveport"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,7,14]]},"container-title":["The Journal of Laryngology & Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215126105532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:37:37Z","timestamp":1789634257000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215126105532\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,14]]},"references-count":0,"alternative-id":["S0022215126105532"],"URL":"https:\/\/doi.org\/10.1017\/s0022215126105532","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,14]]}}}