{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:51:51Z","timestamp":1792050711856,"version":"4.4.0"},"reference-count":32,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0022215126105829_sec1a\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate whether menstrual cycle phase and serum oestrogen influence tympanoplasty outcomes in premenopausal women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126105829_sec2b\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eighty women with small central tympanic membrane perforations (follicular phase, days 1\u20135,\n                      <jats:italic>n<\/jats:italic>\n                      = 40; ovulatory phase, days 12\u201316,\n                      <jats:italic>n<\/jats:italic>\n                      = 40) underwent endoscopic transcanal type I tympanoplasty. Outcomes were anatomical success (at 12 weeks) and hearing improvement. Pre-operative serum oestrogen and its predictive value were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126105829_sec3c\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Graft success was higher in the ovulatory than follicular phase (90\n                      <jats:italic>vs<\/jats:italic>\n                      70 per cent,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.025). Hearing gain was greater in the ovulatory phase (12.35 \u00b1 4.84 dB\n                      <jats:italic>vs<\/jats:italic>\n                      4.70 \u00b1 3.92 dB,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Serum oestrogen was significantly higher in the ovulatory phase. Receiver operating characteristic analysis showed modest predictive performance (area under the curve = 0.643).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215126105829_sec4d\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Tympanoplasty during the ovulatory phase is associated with improved anatomical and functional outcomes, suggesting that endogenous oestrogen benefits tympanic membrane healing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0022215126105829","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:09:22Z","timestamp":1792048162000},"page":"1-6","source":"Crossref","is-referenced-by-count":0,"title":["Influence of menstrual cycle phase and serum oestrogen levels on tympanoplasty outcomes in 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