{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T07:37:56Z","timestamp":1648971476869},"reference-count":41,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,6,3]],"date-time":"2009-06-03T00:00:00Z","timestamp":1243987200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Proc. Nutr. Soc."],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:p>The systematic failure to recognise and appropriately treat children with severe malnutrition has been attributed to the elevated case-fatality rates, often as high as 50%, that still prevail in many hospitals in Africa. Children admitted to Kilifi District Hospital, on the coast of Kenya, with severe malnutrition frequently have life-threatening features and complications, many of which are not adequately identified or treated by WHO guidelines. Four main areas have been identified for research: early identification and better supportive care of sepsis; evidence-based fluid management strategies; improved antimicrobial treatment; rational use of nutritional strategies. The present paper focuses on the identification of children with sepsis and on fluid management strategies.<\/jats:p>","DOI":"10.1017\/s0029665109001359","type":"journal-article","created":{"date-parts":[[2009,6,3]],"date-time":"2009-06-03T05:28:57Z","timestamp":1244006937000},"page":"274-280","source":"Crossref","is-referenced-by-count":5,"title":["Symposium 5: Joint BAPEN and Nutrition Society Symposium on \u2018Feeding size 0: the science of starvation\u2019 Severe malnutrition: therapeutic challenges and treatment of hypovolaemic shock"],"prefix":"10.1017","volume":"68","author":[{"given":"Kathryn","family":"Maitland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,3]]},"reference":[{"key":"S0029665109001359_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11770-3"},{"key":"S0029665109001359_ref033","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/30.3.349"},{"key":"S0029665109001359_ref029","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03470090076035"},{"key":"S0029665109001359_ref012","first-page":"527","article-title":"Management of severe malnutrition in children in tropical climates","volume":"63","author":"Briend","year":"2003","journal-title":"Med Trop (Mars)"},{"key":"S0029665109001359_ref036","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(92)90050-D"},{"key":"S0029665109001359_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15894-7"},{"key":"S0029665109001359_ref022","doi-asserted-by":"publisher","DOI":"10.1136\/adc.76.3.242"},{"key":"S0029665109001359_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13926-8"},{"key":"S0029665109001359_ref017","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030500"},{"key":"S0029665109001359_ref035","doi-asserted-by":"publisher","DOI":"10.1177\/000992289403300304"},{"key":"S0029665109001359_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60565-6"},{"key":"S0029665109001359_ref027","doi-asserted-by":"publisher","DOI":"10.1080\/02724936.1997.11747910"},{"key":"S0029665109001359_ref021","first-page":"711","article-title":"Prevalence of persistent diarrhoea in children aged 3\u201336 months at the Kenyatta National Hospital, Nairobi, Kenya","volume":"72","author":"Mbori-Ngacha","year":"1995","journal-title":"East Afr Med J"},{"key":"S0029665109001359_ref039","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665109001281"},{"key":"S0029665109001359_ref023","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00500-6"},{"key":"S0029665109001359_ref015","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2006.00931.x"},{"key":"S0029665109001359_ref031","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000149131.72248.E6"},{"key":"S0029665109001359_ref025","volume-title":"Cochrane Database of Systematic Reviews, issue 1, CD002847","author":"Hahn","year":"2002"},{"key":"S0029665109001359_ref020","volume-title":"Management of Severe Malnutrition: A Manual for Physicians and Other Senior Health Workers","year":"1999"},{"key":"#cr-split#-S0029665109001359_ref024.1","unstructured":"24. World Health Organization\/UNICEF (2001) Reduced osmolarity oral rehydration salts"},{"key":"#cr-split#-S0029665109001359_ref024.2","unstructured":"(ORS) formulation. http:\/\/whqlibdoc.who.int\/hq\/2001\/WHO_FCH_CAH_01.22.pdf."},{"key":"S0029665109001359_ref040","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602854"},{"key":"S0029665109001359_ref008","first-page":"258","article-title":"Pattern of admissions to the paediatric medical wards (1995 to 1996) at Harare Hospital, Zimbabwe","volume":"45","author":"Nathoo","year":"1999","journal-title":"Cent Afr J Med"},{"key":"S0029665109001359_ref034","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/30.3.334"},{"key":"S0029665109001359_ref001","first-page":"223","article-title":"Why have mortality rates for severe malnutrition remained so high?","volume":"74","author":"Schofield","year":"1996","journal-title":"Bull World Health Organ"},{"key":"S0029665109001359_ref009","first-page":"237","article-title":"Implementation of WHO guidelines on management of severe malnutrition in hospitals in Africa","volume":"81","author":"Deen","year":"2003","journal-title":"Bull World Health Organ"},{"key":"S0029665109001359_ref030","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.678359"},{"key":"S0029665109001359_ref037","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/ajcn\/31.6.911","article-title":"Hemodynamic findings during treatment of protein-calorie malnutrition","volume":"31","author":"Viart","year":"1978","journal-title":"Am J Clin Nutr"},{"key":"S0029665109001359_ref028","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.4.793"},{"key":"S0029665109001359_ref010","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2000.tb01217.x"},{"key":"S0029665109001359_ref026","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07666-3"},{"key":"S0029665109001359_ref002","volume-title":"Guidelines for the Inpatient Treatment of Severely Malnourished Children","author":"Ashworth","year":"2003"},{"key":"S0029665109001359_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07499-6"},{"key":"S0029665109001359_ref016","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2006.00933.x"},{"key":"S0029665109001359_ref038","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000145904.97821.0D"},{"key":"S0029665109001359_ref003","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040045"},{"key":"S0029665109001359_ref005","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmh088"},{"key":"S0029665109001359_ref018","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.5.621"},{"key":"S0029665109001359_ref011","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.087346"},{"key":"S0029665109001359_ref032","first-page":"553","article-title":"Cardiac function in severely malnourished Jamaican children","volume":"30","author":"Alleyne","year":"1966","journal-title":"Clin Sci"},{"key":"S0029665109001359_ref007","first-page":"137","article-title":"Evaluating the clinical management of severely malnourished children \u2013 a study of two rural district hospitals","volume":"91","author":"Puoane","year":"2001","journal-title":"S Afr Med J"}],"container-title":["Proceedings of the Nutrition Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0029665109001359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T08:09:23Z","timestamp":1556611763000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0029665109001359\/type\/journal_article"}},"subtitle":["Conference on \u2018Malnutrition matters\u2019"],"short-title":[],"issued":{"date-parts":[[2009,6,3]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["S0029665109001359"],"URL":"https:\/\/doi.org\/10.1017\/s0029665109001359","relation":{},"ISSN":["0029-6651","1475-2719"],"issn-type":[{"value":"0029-6651","type":"print"},{"value":"1475-2719","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,3]]}}}