{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:59:10Z","timestamp":1793145550939,"version":"4.5.0"},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2011,8,24]],"date-time":"2011-08-24T00:00:00Z","timestamp":1314144000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Proc. Nutr. Soc."],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p>During pregnancy, maternal and fetal Ca demands are met through increased\n                    intestinal Ca absorption. Increased Ca absorption may be more dependent on\n                    oestrogen's up-regulation of Ca transport genes than on vitamin D\n                    status. Numerous studies, however, have found that severe vitamin D deficiency\n                    with secondary hyperparathyroidism during pregnancy leads to abnormal Ca\n                    homoeostasis in the neonate. Some, but not all, studies of maternal vitamin D\n                    supplementation during pregnancy find a greater birth weight among infants of\n                    mothers with adequate vitamin D status. Observational studies find a higher\n                    incidence of small-for-gestational age (SGA) infants among\n                    mothers who are vitamin D deficient, but this effect may be modified by\n                    genetics. In addition, the effect of vitamin D status on SGA may not be linear,\n                    with increased occurrence of SGA at high maternal 25-hydroxyvitamin D\n                    (25-OHD) concentrations. Some studies, but not all, also\n                    have found that maternal vitamin D status is associated with growth trajectory\n                    during the first year of life, although the findings are contradictory. There\n                    are recent studies that suggest maternal 25-OHD, or surrogates of vitamin D\n                    status, are associated with growth and bone mass later in childhood. These\n                    results are not consistent, and blinded randomised trials of vitamin D\n                    supplementation during pregnancy with long-term follow-up are needed to\n                    determine the benefits, and possible risks, of maternal vitamin D status on\n                    offspring growth and bone development. The possibility of adverse outcomes with\n                    higher maternal 25-OHD concentrations should be considered and investigated in\n                    all ongoing and future studies.<\/jats:p>","DOI":"10.1017\/s0029665111003053","type":"journal-article","created":{"date-parts":[[2011,8,24]],"date-time":"2011-08-24T09:54:48Z","timestamp":1314179688000},"page":"38-45","source":"Crossref","is-referenced-by-count":32,"title":["Does vitamin D during pregnancy impact offspring growth and\n                    bone?"],"prefix":"10.1017","volume":"71","author":[{"given":"Bonny L.","family":"Specker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2011,8,24]]},"reference":[{"key":"S0029665111003053_ref016","first-page":"488","article-title":"Effect of vitamin D supplementation during pregnancy on foetal\n                    growth","volume":"88","author":"Marya","year":"1988","journal-title":"Indian J Med Res"},{"key":"S0029665111003053_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)90857-X"},{"key":"S0029665111003053_ref033","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.1040508"},{"key":"S0029665111003053_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80396-1"},{"key":"S0029665111003053_ref031","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1391"},{"key":"S0029665111003053_ref012","first-page":"1","article-title":"Maternal vitamin D intake and mineral metabolism in mothers and\n                    their newborn infants","volume":"231","author":"Cockburn","year":"1980","journal-title":"Br Med J"},{"key":"S0029665111003053_ref005","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.10.1725"},{"key":"S0029665111003053_ref018","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2009.27"},{"key":"S0029665111003053_ref030","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80236-7"},{"key":"S0029665111003053_ref035","volume-title":"Food and\n                    Nutrition Board. 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Javaid MK , Shore SR , Taylor P (2003) Maternal vitamin D status during late pregnancy and accrual of childhood bone mineral. American Society for Bone and Mineral Research Annual Meeting, Minneapolis."},{"key":"S0029665111003053_ref021","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.119636"},{"key":"S0029665111003053_ref006","first-page":"10","article-title":"Vitamin D deficiency in pregnant and breast-feeding women and\n                    their infants","volume":"17","author":"Daaboul","year":"1997","journal-title":"J Perinatol"},{"key":"S0029665111003053_ref002","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-60-5-880"},{"key":"S0029665111003053_ref001","first-page":"330","volume-title":"Scientific\n                    Foundations of Pediatrics","author":"Widdowson","year":"1981"},{"key":"S0029665111003053_ref015","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-198609000-00002"},{"key":"S0029665111003053_ref019","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.283.6298.1024"},{"key":"S0029665111003053_ref010","first-page":"1234","article-title":"Mineral content of the forearms of babies born to Asian and white\n                    mothers","volume":"286","author":"Congdon","year":"1983","journal-title":"BMJ"},{"key":"S0029665111003053_ref020","doi-asserted-by":"publisher","DOI":"10.1017\/S000711451000022X"},{"key":"S0029665111003053_ref027","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-47-562-732"},{"key":"S0029665111003053_ref023","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602680"},{"key":"S0029665111003053_ref004","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/61.3.514"},{"key":"S0029665111003053_ref009","first-page":"95","article-title":"25-Hydroxyvitamin D and calcium levels in maternal, cord and\n                    infant serum in relation to maternal vitamin D intake","volume":"33","author":"Paunier","year":"1978","journal-title":"Helv Paediatr Acta"}],"container-title":["Proceedings of the Nutrition Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0029665111003053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T01:55:06Z","timestamp":1556243706000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0029665111003053\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,24]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0029665111003053"],"URL":"https:\/\/doi.org\/10.1017\/s0029665111003053","relation":{},"ISSN":["0029-6651","1475-2719"],"issn-type":[{"value":"0029-6651","type":"print"},{"value":"1475-2719","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,24]]}}}