{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:16:06Z","timestamp":1791270966603,"version":"4.1.0"},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T00:00:00Z","timestamp":1172620800000},"content-version":"unspecified","delay-in-days":2768,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Proc. Nutr. Soc."],"published-print":{"date-parts":[[1999,8]]},"abstract":"<jats:p>Oxidant stress is increasingly becoming an important hypothesis to explain the genesis of several pathologies, including cancer, atherosclerosis and also ageing. Beside a few rare genetic defects, dietary factors are thought to play a key role in the regulation of the production of reactive oxygenated species. An imbalance between nutrients, and in particular those involved in antioxidant status, could explain the onset of an enhanced production of free radicals. We will briefly review information concerning oxidation of lipids and lipoproteins which lead to atherothrombosis. We also present new findings supporting a role for blood platelets in generating oxidant species. New data are also described concerning the role of oxygenated derivatives of cholesterol, oxysterols, in cellular cholesterol efflux and NO production. Also, new developments relating to the influence of direct effects of free radicals on cellular cholesterol homeostasis are presented. Finally, the in vitro effects of butyrate, a natural short-chain fatty acid produced by bacterial fermentation, in the protection against free radical-mediated cytotoxicity are discussed. These data provide information on the mechanisms of dietary antioxidants in preventing oxidant stress.R\u00e9sum\u00e9 Au c\u00f4t\u00e9 des rares cas d\u2019origine g\u00e9n\u00e9tique, les facteurs nutritionnels (d\u00e9s\u00e9quilibres alimentaires, d\u00e9ficience en nutriments antioxydants) jouent des r\u00f4les cruciaux dans la modulation de la production d\u2019esp\u00e8ces actives de l\u2019oxyg\u00e8ne, conduisant \u00e0 l\u2019\u00e9tablissement d\u2019un stress oxydant, situation m\u00e9tabolique de plus en plus reconnue comme susceptible d\u2019\u00eatre \u00e0 l\u2019origine de nombreuses pathologies comme les cancers, l\u2019ath\u00e9roscl\u00e9rose et \u00e9galement le vieillissement. Apr\u00e8s avoir bri\u00e8vement rappel\u00e9 les donn\u00e9es concernant l\u2019oxydation des lipides et des lipoprot\u00e9ines susceptibles de conduire au d\u00e9veloppement de l\u2019ath\u00e9ro-thrombogen\u00e8se, nous pr\u00e9sentons des donn\u00e9es r\u00e9centes et originales indiquant que les plaquettes sont en fait capables \u00e0 l\u2019instar d\u2019autres cellules, de produire des formes actives de l\u2019oxyg\u00e8ne susceptibles de modifier les LDL. Des r\u00e9sultats originaux sont \u00e9galement expos\u00e9s concernant l\u2019effets des oxyst\u00e9rols, produits d\u2019oxydation du cholest\u00e9rol g\u00e9n\u00e9r\u00e9s au cours de l\u2019oxydation des LDL ou pr\u00e9sents dans l\u2019alimentation, sur deux param\u00e8tres importants comme l\u2019efflux du cholest\u00e9rol cellulaire et la production de monoxyde d\u2019azote. De plus, des donn\u00e9es nouvelles relatives \u00e0 l\u2019effets du stress oxydant et son inhibition par des antioxydants d\u2019origine nutritionnelle sont expos\u00e9es sur l\u2019hom\u00e9ostasie du cholest\u00e9rol cellulaire. Enfin, dans ce contexte, les effets potentiellement antiath\u00e9rog\u00e8nes d\u2019un acide gras \u00e0 courte cha\u00eene produit par la fermentation bact\u00e9rienne, le butyrate, sont d\u00e9crits sur la protection de cellules en culture vis-\u00e0-vis d\u2019un stress oxydant in vitro. Ces \u00e9l\u00e9ments contribuent \u00e0 apporter de nouvelles informations renfor\u00e7ant la notion de fonctionnalit\u00e9 des nutriments dans la protection du stress oxydant en relation avec la pathogen\u00e8se.<\/jats:p>","DOI":"10.1017\/s0029665199000737","type":"journal-article","created":{"date-parts":[[2011,2,25]],"date-time":"2011-02-25T11:25:07Z","timestamp":1298633107000},"page":"559-563","source":"Crossref","is-referenced-by-count":17,"title":["Oxidant stress: the role of nutrients in cell-lipoprotein 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