{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:05:52Z","timestamp":1762160752627},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":10657,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1980,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In female NIH strain mice, expulsion of a primary infection of the nematode<jats:italic>Trichinella spiralis<\/jats:italic>began on day 8 and was virtually complete by day 14 of infection. In secondary and tertiary infections, the number of larvae which established in the intestine was normal, but expulsion began on day 6 and was complete on day 10. In a primary infection the shedding of larvae by female worms began on day 5, reached its peak on days 6\u20137, began to decrease on day 8 and was minimal by day 10. In secondary and tertiary infections fecundity was depressed. The depression of fecundity occurred slightly in advance of worm loss. During the stable phase of infection,<jats:italic>T. spiralis<\/jats:italic>occurred in the anterior half of the small intestine. During expulsion, living worms were found increasingly in more posterior parts of the gut but their fecundity did not vary with position. After direct inoculation into the posterior ileum, adult and larval<jats:italic>T. spiralis<\/jats:italic>remained in the posterior half of the small intestine. In this position, larvae established in normal numbers, grew and reproduced normally. Therefore, any part of the small intestine was a suitable site for<jats:italic>T. spiralis<\/jats:italic>and expulsion is not merely due to a change in the position of the worms.<\/jats:p>","DOI":"10.1017\/s0031182000000500","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T16:49:10Z","timestamp":1244220550000},"page":"49-60","source":"Crossref","is-referenced-by-count":15,"title":["Effects of the host immune response on the longevity, fecundity and position in the intestine of<i>Trichinella spiralis<\/i>in mice"],"prefix":"10.1017","volume":"80","author":[{"given":"M. W.","family":"Kennedy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000000500_ref017","doi-asserted-by":"publisher","DOI":"10.2307\/3273393"},{"key":"S0031182000000500_ref011","unstructured":"Fatunmbi O. O. (1978). Studies on some aspects of the development of Trichinella spiralis in mice. M.Sc. Dissertation, University of Glasgow."},{"key":"S0031182000000500_ref026","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000049507"},{"key":"S0031182000000500_ref023","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/88.3.248"},{"key":"S0031182000000500_ref016","first-page":"1","article-title":"A study of the distribution and longevity of adult Trichinella spiralis in immunized and non-immunized mice","volume":"68","author":"Larsh","year":"1952","journal-title":"Journal of the Elisha Mitchell Scientific Society"},{"key":"S0031182000000500_ref014","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000049180"},{"key":"S0031182000000500_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(78)90042-5"},{"key":"S0031182000000500_ref006","first-page":"343","volume-title":"Biochemistry of Parasites and Host \u2013 Parasite Relationships","author":"Castro","year":"1976"},{"key":"S0031182000000500_ref004","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1017\/S0031182000070402","article-title":"The migration of Hymenolepis diminuta in the rat's intestine during normal development and following surgical transplantation","volume":"59","author":"Br\u00e5ten","year":"1969","journal-title":"Parasitology"},{"key":"S0031182000000500_ref001","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000041299"},{"key":"S0031182000000500_ref005","doi-asserted-by":"publisher","DOI":"10.2307\/3276598"},{"key":"S0031182000000500_ref021","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X0000763X"},{"key":"S0031182000000500_ref008","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00017843"},{"key":"S0031182000000500_ref015","first-page":"213","volume-title":"Advances in Parasitology","volume":"1","author":"Larsh","year":"1963"},{"key":"S0031182000000500_ref009","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00022021"},{"key":"S0031182000000500_ref002","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200004779X"},{"key":"S0031182000000500_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000068785"},{"key":"S0031182000000500_ref022","first-page":"633","article-title":"Localization of intestinal trichinellae in the small intestines of mice in their intestinal phase","volume":"8","author":"Podh\u00e1jecky","year":"1962","journal-title":"Wiadomosci Parazytologiczne"},{"key":"S0031182000000500_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(75)90077-6"},{"key":"S0031182000000500_ref013","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000028924"},{"key":"S0031182000000500_ref024","first-page":"xliii","article-title":"Site selection behaviour of Trichinella spiralis in Swiss mice","volume":"77","author":"Sukhdeo","year":"1978","journal-title":"Parasitology"},{"key":"S0031182000000500_ref019","first-page":"7","article-title":"The immune mechanism which expels the intestinal stage of Trichinella spiralis from rats","volume":"30","author":"Love","year":"1976","journal-title":"Immunology"},{"key":"S0031182000000500_ref010","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000047570"},{"key":"S0031182000000500_ref020","first-page":"484","article-title":"Immunity of rats to reinfection with Trichinella spiralis","volume":"14","author":"Mccoy","year":"1931","journal-title":"American Journal of Hygiene"},{"key":"S0031182000000500_ref007","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000069006"},{"key":"S0031182000000500_ref025","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000048472"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000000500","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T07:20:38Z","timestamp":1589872838000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000000500\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,2]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1980,2]]}},"alternative-id":["S0031182000000500"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000000500","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,2]]}}}