{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:32:30Z","timestamp":1762075950861},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"3-4","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":18754,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1957,12]]},"abstract":"<jats:p>A study of neutralization reaction of trypanosomes with immune sera made against them is recorded, together with a description of the technique.<\/jats:p><jats:p>Neutralizing antibody appears in rabbits infected with<jats:italic>T. brucei<\/jats:italic>5 days after infection and reaches its peak (1\/320) within 28 days.<\/jats:p><jats:p>The same titre of neutralizing antibody can be produced in rabbits by a series of injections of dead formalized trypanosomes.<\/jats:p><jats:p>Antibody titres persist at high levels for a longer period in animals infected and subsequently treated than in animals immunized with dead trypanosomes.<\/jats:p><jats:p>Neutralizing antibody can be demonstrated in infected guinea-pigs but on a much lower level than in rabbits. Mice and rats infected with<jats:italic>T. brucei<\/jats:italic>and not treated failed to show demonstrable neutralizing antibody.<\/jats:p><jats:p>Mice infected with<jats:italic>T. brucei<\/jats:italic>can be protected from infection by inoculation at the same time, or even 1 hr. later, with 0\u00b75 ml. of antiserum showing a high level of neutralizing antibody.<\/jats:p><jats:p>Mice inoculated with the same antiserum showed passive immunity lasting for 10 days.<\/jats:p><jats:p>The evidence that<jats:italic>T. brucei<\/jats:italic>\u2018O\u2018 after passages through rabbits failed to be neutralized by homologous or heterologous sera which, on the other hand, were able to neutralize the parent strain, suggests that strains after passage through rabbits were not genetic variants, but developed a protective mechanism against immune bodies.<\/jats:p>","DOI":"10.1017\/s003118200002206x","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T17:48:50Z","timestamp":1244224130000},"page":"375-389","source":"Crossref","is-referenced-by-count":36,"title":["Immunity in trypanosomiasis I. 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Wschr."},{"key":"S003118200002206X_ref008","first-page":"785","article-title":"Recherches sur le traitement et la pr\u00e9vention du nagana","volume":"16","author":"Laveran","year":"1902","journal-title":"Ann. Inst. Pasteur"},{"key":"S003118200002206X_ref001","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1189237"},{"key":"S003118200002206X_ref002","first-page":"94","article-title":"Ueber chemotherapie","volume":"50","author":"Ehrlich","year":"1911","journal-title":"Zbl. Bakt."},{"key":"S003118200002206X_ref014","first-page":"129","article-title":"Sur les propri\u00e9t\u00e9s protectrices du s\u00e9rum des animaux trypanosomies. Races r\u00e9sistantes \u00e0 ces s\u00e9rums","volume":"23","author":"Mesnil","year":"1909","journal-title":"Ann. Inst. Pasteur."},{"key":"S003118200002206X_ref013","doi-asserted-by":"publisher","DOI":"10.1007\/BF02199366"},{"key":"S003118200002206X_ref015","first-page":"416","article-title":"Studies in immunity to trypanosomes. I. 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