{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:31:51Z","timestamp":1756996311208,"version":"3.37.0"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":13519,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1972,4]]},"abstract":"<jats:p>In rats treated with compound 48\/80 or histamine, worm expulsion was inhibited. Treatment with a histidine decarboxylase inhibitor accelerated worm expulsion. Treatment with compound 48\/80 elevates histamine and histidine decarboxylase levels and reduces circulating reagin titres. These results show that histamine is not responsible for worm expulsion.<\/jats:p><jats:p>Compounds such as isoprenaline and theophylline which increase cellular levels of cyclic 3\u2032,5-AMP, prevented worm expulsion.<\/jats:p><jats:p>It is concluded that the evidence that amines are involved in worm expulsion needs reassessing and that cellular release mechanisms in general may be affected by drugs thought to act solely on amine release. In particular, the release of effector substances from sensitized lymphocytes on contact with antigen may be affected by these treatments.<\/jats:p><jats:p>The skilful technical assistance of Miss R. Keist and Miss I. Beeger is gratefully acknowledged. We thank Mr H. Berchtold, Biostatistisches Zentrum der Universit\u00e4t Z\u00fcrich, for the statistical evaluation of the data.<\/jats:p>","DOI":"10.1017\/s0031182000029644","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T17:06:29Z","timestamp":1244221589000},"page":"217-227","source":"Crossref","is-referenced-by-count":15,"title":["The effects of drugs on worm expulsion in the<i>Nippostrongylus brasiliensis<\/i>infected rat: a discussion of the interpretation of drug action"],"prefix":"10.1017","volume":"64","author":[{"given":"R.","family":"Keller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bridget M.","family":"Ogilvie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000029644_ref023","doi-asserted-by":"publisher","DOI":"10.2307\/3276966"},{"key":"S0031182000029644_ref003","first-page":"99","article-title":"Propri\u00e9t\u00e9s antihistaminiques de la N-p-m\u00e9thoxybenzyl-N-dim\u00e9thylamino\u00e9thyl \u03b1 amino-pyridine","volume":"138","author":"Bovet","year":"1944","journal-title":"Comptes Rendus des S\u00e9ances de la Soci\u00e9t\u00e9 de Biologie"},{"key":"S0031182000029644_ref020","doi-asserted-by":"publisher","DOI":"10.1159\/000230408"},{"key":"S0031182000029644_ref017","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.11.3.607"},{"key":"S0031182000029644_ref016","doi-asserted-by":"publisher","DOI":"10.1126\/science.161.3844.902"},{"key":"S0031182000029644_ref014","first-page":"565","article-title":"Immunological analysis of the primary and secondary reagin response to Nippostrongylus brasiliensis in the rat","volume":"21","author":"Keller","year":"1971","journal-title":"Immunology"},{"key":"S0031182000029644_ref026","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700690135"},{"key":"S0031182000029644_ref013","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000079993"},{"key":"S0031182000029644_ref001","doi-asserted-by":"publisher","DOI":"10.1038\/2241028a0"},{"key":"S0031182000029644_ref011","first-page":"207","article-title":"On the mechanism of expulsion of helminths","volume":"6","author":"Keller","year":"1970","journal-title":"Clinical and experimental Immunology"},{"key":"S0031182000029644_ref005","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000040816"},{"key":"S0031182000029644_ref025","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1968.tb08484.x"},{"key":"S0031182000029644_ref009","first-page":"549","article-title":"Protective immunity to Nippostrongylus brasiliensis: the sequence of events which expels worms from the rat intestine","volume":"20","author":"Jones","year":"1971","journal-title":"Immunology"},{"key":"S0031182000029644_ref031","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1967.tb03625.x"},{"key":"S0031182000029644_ref024","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(71)90021-X"},{"key":"S0031182000029644_ref021","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000068797"},{"key":"S0031182000029644_ref022","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1017\/S0031182000086285","article-title":"Use of cortisone derivatives to inhibit resistance to Nippostrongylus brasiliensis and to study the fate of parasites in resistant hosts","volume":"55","author":"Ogilvie","year":"1965","journal-title":"Parasitology"},{"key":"S0031182000029644_ref002","first-page":"537","article-title":"Ueber die Wirkungsdauer einiger Serotoninantogonisten","volume":"18","author":"Berde","year":"1960","journal-title":"Helvetica physiologica et pharmacologica Acta"},{"key":"S0031182000029644_ref027","first-page":"40","article-title":"Autoradiographische Untersuchungen zur DNS-Neubildung und zum Sulfateinbau in Gewebemastzellen","volume":"73","author":"Roth","year":"1963","journal-title":"Frankfurter Zeitschrift f\u00fcr Pathologie"},{"key":"S0031182000029644_ref007","doi-asserted-by":"publisher","DOI":"10.1007\/BF01240946"},{"key":"S0031182000029644_ref028","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1152\/ajplegacy.1959.196.2.295","article-title":"Increase in histidine decarboxylase activity of rat skin following treatment with compound 48\/80","volume":"196","author":"Schayer","year":"1959","journal-title":"American Journal of Physiology"},{"key":"S0031182000029644_ref019","first-page":"222","article-title":"The globule leukocyte and its derivation from the subepithelial mast cell","volume":"19","author":"Murray","year":"1968","journal-title":"Laboratory Investigation"},{"key":"S0031182000029644_ref010","doi-asserted-by":"publisher","DOI":"10.1159\/000230233"},{"key":"S0031182000029644_ref004","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/S0021-9258(18)60316-3","article-title":"Adenosine 3\u2032,5\u2032-phosphate in biological materials. 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