{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T03:04:13Z","timestamp":1712891053047},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":14493,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1969,8]]},"abstract":"<jats:p>In the system investigated the spleen was essential in most rats for the acquisition of immunity and its maintenance in the presence of the piroplasm.<\/jats:p><jats:p>It is stressed that model immunological systems involving the role of the spleen do not simulate the complexity of a parasitic infection. The roles of the spleen as an antibody producer, and as a site of phagocytosis and haemopoiesis are discussed in relation to the control of<jats:italic>Babesia rodhaini<\/jats:italic>by the rat. The possibility that the piroplasm may be able to undergo antigenic variation is considered.<\/jats:p>","DOI":"10.1017\/s0031182000031176","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T17:15:02Z","timestamp":1244222102000},"page":"637-648","source":"Crossref","is-referenced-by-count":19,"title":["The role of the spleen in relation to natural and acquired immunity to infections of<i>Babesia rodhaini<\/i>in the rat"],"prefix":"10.1017","volume":"59","author":[{"given":"R. S.","family":"Phillips","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000031176_ref028","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1182\/blood.V26.1.49.49","article-title":"The removal of in vitro damaged erythrocytes from the circulation of normal and splenectomized rats","volume":"26","author":"Ultmann","year":"1965","journal-title":"Blood"},{"key":"S0031182000031176_ref027","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(67)90096-3"},{"key":"S0031182000031176_ref026","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1956.5.391"},{"key":"S0031182000031176_ref025","first-page":"11","article-title":"Piroplasmosis in man-report on a case","volume":"9","author":"Skrabalo","year":"1957","journal-title":"Documenta. Med. geogr. trop."},{"key":"S0031182000031176_ref024","doi-asserted-by":"crossref","first-page":"289","DOI":"10.4049\/jimmunol.64.4.289","article-title":"The effect of splenectomy on the formation of circulating antibody in the adult male albino rat","volume":"64","author":"Rowley","year":"1950","journal-title":"J. Immun."},{"key":"S0031182000031176_ref023","volume-title":"Immunity to the Protozoa","author":"Riek","year":"1963"},{"key":"S0031182000031176_ref022","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1152\/ajplegacy.1967.212.4.897","article-title":"Some properties of rat erythrocytes after splenectomy and reimplanted spleens","volume":"212","author":"Rieber","year":"1967","journal-title":"Am. J. Physiol."},{"key":"S0031182000031176_ref020","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000082329"},{"key":"S0031182000031176_ref029","doi-asserted-by":"crossref","first-page":"891","DOI":"10.4049\/jimmunol.89.6.891","article-title":"Antibody formation in the rat. I. Agglutinin response to particulate flagella from Salmonella typhosa","volume":"89","author":"Winebright","year":"1962","journal-title":"J. Immun."},{"key":"S0031182000031176_ref015","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104832"},{"key":"S0031182000031176_ref014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1959.tb04383.x"},{"key":"S0031182000031176_ref013","doi-asserted-by":"publisher","DOI":"10.1038\/217861a0"},{"key":"S0031182000031176_ref007","first-page":"109","article-title":"Spleen cell migration in the immune response of the rat","volume":"84","author":"Cannon","year":"1967","journal-title":"Archs Path."},{"key":"S0031182000031176_ref021","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000082317"},{"key":"S0031182000031176_ref019","unstructured":"Phillips R. S. (1968). Studies on Babesia rodhaini in laboratory animals. Ph.D. thesis, University of Cambridge."},{"key":"S0031182000031176_ref018","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1965.tb06609.x"},{"key":"S0031182000031176_ref012","first-page":"109","article-title":"Factors associated with immunization of mice with soluble serum antigens of Plasmodium gallinaceum","volume":"19","author":"Ferris","year":"1968","journal-title":"Z. Tropenmed. Parasit."},{"key":"S0031182000031176_ref010","first-page":"505","article-title":"Influence of splenectomy in rats on the formation of I9S and 7S antibodies","volume":"12","author":"De Carvalho","year":"1967","journal-title":"Immunology"},{"key":"S0031182000031176_ref009","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1964.tb00689.x"},{"key":"S0031182000031176_ref003","doi-asserted-by":"publisher","DOI":"10.1084\/jem.110.1.27"},{"key":"S0031182000031176_ref004","first-page":"263","article-title":"Immunological responsiveness following the continuous circulation of soluble antigen-antibody complexes","volume":"15","author":"Boyns","year":"1968","journal-title":"Immunology"},{"key":"S0031182000031176_ref017","unstructured":"Matson B. A. (1964). Tick transmission in Babesia divergens and immunity in B. rodhaini. Ph.D. thesis, University of Cambridge. (Summary: Vet. Bull., Weybridge (1967), 37, 97."},{"key":"S0031182000031176_ref006","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-124-31794"},{"key":"S0031182000031176_ref001","doi-asserted-by":"publisher","DOI":"10.1042\/bj0680252"},{"key":"S0031182000031176_ref008","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1968.17.13"},{"key":"S0031182000031176_ref002","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0034-5288(18)34718-0","article-title":"The chemotherapy of Babesia bigemina infection in cattle","volume":"6","author":"Barnett","year":"1965","journal-title":"Res. vet. Sci."},{"key":"S0031182000031176_ref011","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1542\/peds.37.1.111","article-title":"The role of the spleen in immunity","volume":"37","author":"Ellis","year":"1966","journal-title":"Pediatrics"},{"key":"S0031182000031176_ref005","doi-asserted-by":"publisher","DOI":"10.1038\/2081286a0"},{"key":"S0031182000031176_ref016","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-193208000-00008"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000031176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T09:26:14Z","timestamp":1710408374000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000031176\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,8]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1969,8]]}},"alternative-id":["S0031182000031176"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000031176","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1969,8]]}}}