{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:26:03Z","timestamp":1792718763505,"version":"4.5.0"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":10291,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1981,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Variant antigenic types (VATs) represented in a total of 47 first relapse populations of 6 clones of <jats:italic>Trypanosoma brucei<\/jats:italic> LUMP 227 were identified by immunofluorescent staining of living trypanosomes, using antiserum raised against purified surface antigens. The relative growth rates of these 6 clones were measured both individually and when grown together in a mixed population, and were found to be different under these two sets of conditions. A pattern emerged in the VATs represented in relapses of each clone, with some types being expressed more frequently than others and certain VATs being only very rarely expressed. It is suggested that new VATs are expressed according to a statistically definable order of priority which is different for each parent VAT, and that some VATs may be able to change to certain others only after passing through an intermediate VAT. The order of priority of appearance of VATs does not appear to correlate with growth rate measured either in individual clones or when clones are grown in a mixed population.<\/jats:p>","DOI":"10.1017\/s0031182000041871","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T12:44:44Z","timestamp":1244205884000},"page":"63-80","source":"Crossref","is-referenced-by-count":100,"title":["Analysis of antigenic types appearing in first relapse populations of clones of <i>Trypanosoma brucei<\/i>"],"prefix":"10.1017","volume":"82","author":[{"given":"E. N.","family":"Miller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000041871_ref007","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1965.11686278"},{"key":"S0031182000041871_ref002","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200004717X"},{"key":"S0031182000041871_ref015","first-page":"113","article-title":"Studies on the immunological variation in Trypanosoma gambiense (serotypes and the mode of relapse)","volume":"2","author":"Osaki","year":"1959","journal-title":"Biken's Journal"},{"key":"S0031182000041871_ref016","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1978.tb04179.x"},{"key":"S0031182000041871_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(66)90024-1"},{"key":"S0031182000041871_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(77)90055-8"},{"key":"S0031182000041871_ref008","first-page":"493","volume-title":"Biology of the Kinetoplastida","author":"Gray","year":"1976"},{"key":"S0031182000041871_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(63)90032-8"},{"key":"S0031182000041871_ref004","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-8855-9_4"},{"key":"S0031182000041871_ref005","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000000810"},{"key":"S0031182000041871_ref006","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1962.11686083"},{"key":"S0031182000041871_ref009","doi-asserted-by":"publisher","DOI":"10.1214\/aoms\/1177705684"},{"key":"S0031182000041871_ref011","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1937.11684987"},{"key":"S0031182000041871_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(69)90046-0"},{"key":"S0031182000041871_ref017","unstructured":"Taylor D. W. (1977) Antigenic variation in Trypanosoma brucei. Ph.D. thesis, University of Cambridge."},{"key":"S0031182000041871_ref018","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-32-1-145"},{"key":"S0031182000041871_ref010","first-page":"357","article-title":"Studies on the immunological variations in Trypanosoma gambiense. A new variation system and a new experimental method","volume":"3","author":"Inoki","year":"1952","journal-title":"Medical Journal of Osaka University"},{"key":"S0031182000041871_ref013","first-page":"1","article-title":"Antigenic variation in syringe-passaged populations of Trypanosoma (Trypanozoon) brucei. Rationalization of the experimental approach","volume":"55","author":"Van Meirvenne","year":"1975","journal-title":"Annales de la Soci\u00e9t\u00e9 Belge de M\u00e9dicine Tropicale"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000041871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T16:44:09Z","timestamp":1558802649000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000041871\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,2]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1981,2]]}},"alternative-id":["S0031182000041871"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000041871","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,2]]}}}