{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T10:06:17Z","timestamp":1695981977237},"reference-count":11,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":13213,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1973,2]]},"abstract":"<jats:p>Mice infected with as few as ten eggs of the nematode <jats:italic>Trichuris muris<\/jats:italic> are highly resistant to a challenge infection given 5 weeks later. The rate of elimination of challenge larvae is similar in mice immunized by infection with ten or with 300 eggs. Stimulation of immunity to challenge by the low-level infections is dependent upon the persistence of the immunizing worm population and removal of the population at day 14 considerably reduces the level of immunity. Worms developing from a low-level immunizing infection are not eliminated by a \u2018self-cure\u2019 response, as is the case with larger infections, and become sexually mature. Adult worms from such an infection are, however, eliminated by the response to a superimposed challenge infection. Repeated infection of mice with small numbers of eggs stimulates an immune response and the worm population is eliminated before patency.<\/jats:p>","DOI":"10.1017\/s0031182000044528","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T13:04:29Z","timestamp":1244207069000},"page":"181-189","source":"Crossref","is-referenced-by-count":33,"title":["The stimulation of immunity to <i>Trichuris muris<\/i> in mice exposed to low-level infections"],"prefix":"10.1017","volume":"66","author":[{"given":"D.","family":"Wakelin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000044528_ref002","first-page":"176","article-title":"Effect of population density on adult worm survival in primary Nippostrongylus brasiliensis infections in the rat","volume":"28","author":"Haley","year":"1961","journal-title":"Proceedings of the Helminthological Society of Washington"},{"key":"S0031182000044528_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(67)90102-2"},{"key":"S0031182000044528_ref011","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000031097"},{"key":"S0031182000044528_ref008","doi-asserted-by":"publisher","DOI":"10.1007\/BF00331471"},{"key":"S0031182000044528_ref010","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000072395"},{"key":"S0031182000044528_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(71)90021-X"},{"key":"S0031182000044528_ref005","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200007760X"},{"key":"S0031182000044528_ref006","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000068797"},{"key":"S0031182000044528_ref004","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000028924"},{"key":"S0031182000044528_ref003","first-page":"91","article-title":"Immunization threshold in laboratory rats given a small initial infection of Nippostrongylus muris","volume":"26","author":"Hurley","year":"1959","journal-title":"Proceedings of the Helminthological Society of Washington"},{"key":"S0031182000044528_ref001","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00017843"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000044528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T16:10:27Z","timestamp":1559232627000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000044528\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,2]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1973,2]]}},"alternative-id":["S0031182000044528"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000044528","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,2]]}}}