{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:41:02Z","timestamp":1779334862084,"version":"3.51.4"},"reference-count":9,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":13154,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1973,4]]},"abstract":"<jats:p>The effect of oxyclozanide (2,2\u2032-dihydroxy-3,3\u2032,5,5\u2032,6-pentachlorobenzanilide) on <jats:italic>Hymenolepis microstoma<\/jats:italic> in the bile duct of mice, and <jats:italic>H. diminuta<\/jats:italic> in the small intestine of mice and rats was measured.\nOxyclozanide at doses as low as 4mg\/kg removed 13-day-old <jats:italic>H. diminuta<\/jats:italic> and caused no obvious harmful effect to the rat host up to the maximum level (256 mg\/kg) tested. Worms were displaced and degenerating within 1 h. Results in mice were more difficult to assess because of the immune response, but similar total amounts of oxyclozanide caused destrobilation and loss of 7-day-old <jats:italic>H. diminuta<\/jats:italic>.\nOxyclozanide was less effective against 21-day-old <jats:italic>H. microstoma<\/jats:italic> attached in the bile duct. Approximately half the strobila was lost following dosing at 5 mg\/kg and progressively greater amounts as the dose level was increased. At 50 mg\/kg worm loss commenced but even at 150 mg\/kg 25 % of worms survived. The time taken to regrow to the original adult size varied but was complete within 7\u20139 days at levels up to 25 mg\/kg. Double dosing at 5-day intervals did not enhance the effect of a single dose. The apparent existence of a sensitivity gradient down the strobila in <jats:italic>H. microstoma<\/jats:italic> is discussed.<\/jats:p>","DOI":"10.1017\/s0031182000045285","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T17:04:22Z","timestamp":1244221462000},"page":"355-365","source":"Crossref","is-referenced-by-count":27,"title":["The effect of oxyclozanide on <i>Hymenolepis microstoma<\/i> and <i>H. diminuta<\/i>"],"prefix":"10.1017","volume":"66","author":[{"given":"C. A.","family":"Hopkins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. M.","family":"Grant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Stallard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000045285_ref008","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/BF00259337","article-title":"Distribution and growth of Hymenolepis diminuta in the rat, hamster and mouse","volume":"37","author":"Turton","year":"1971","journal-title":"Zeitschrift f\u00fcr Parasitenkunde"},{"key":"S0031182000045285_ref009","doi-asserted-by":"publisher","DOI":"10.1136\/vr.78.8.267"},{"key":"S0031182000045285_ref001","doi-asserted-by":"publisher","DOI":"10.1038\/210744a0"},{"key":"S0031182000045285_ref005","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000044279"},{"key":"S0031182000045285_ref002","first-page":"564","article-title":"Stilesia infestation in sheep","volume":"84","author":"Harrow","year":"1969","journal-title":"The Veterinary Record"},{"key":"S0031182000045285_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000078094"},{"key":"S0031182000045285_ref004","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000045479"},{"key":"S0031182000045285_ref006","doi-asserted-by":"publisher","DOI":"10.2307\/3274331"},{"key":"S0031182000045285_ref007","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000071511"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000045285","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T19:58:41Z","timestamp":1559246321000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000045285\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,4]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1973,4]]}},"alternative-id":["S0031182000045285"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000045285","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,4]]}}}