{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:35:15Z","timestamp":1759991715324},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":12667,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1974,8]]},"abstract":"<jats:p>The ultrastructural changes in the encysted phase of <jats:italic>Trichinella<\/jats:italic> larvae, during and after treatment of the rat with mebendazole, were studied.<\/jats:p><jats:p>The earliest modifications in the infected area concerned the immediate larval environment (matrix). These degenerative changes in the matrix were seen before any alteration could be observed in the larvae.<\/jats:p><jats:p>Subsequently, oedematous swelling, intracellular vacuolization and loss of glycogen were noted in the larval cells.<\/jats:p><jats:p>Together with the progressive involution of the larvae and their matrix, inflammatory and immunocompetent cells invade the infected area and penetrate the altered capsule. Calcification of the larvae and massive infiltration of mononuclear phagocytes with subsequent elimination of the calcified remnants were the prominent features in the first weeks after treatment. The infected areas were completely cleared from larval and matrix residues 50 days after the end of treatment and a nearly normalized tissue was seen from day 111 after treatment.<\/jats:p>","DOI":"10.1017\/s0031182000046175","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T13:02:02Z","timestamp":1244206922000},"page":"55-62","source":"Crossref","is-referenced-by-count":11,"title":["Effects of mebendazole on the encysted phase of <i>Trichinella spiralis<\/i> in the rat: an electron-microscope study"],"prefix":"10.1017","volume":"69","author":[{"given":"Sonja De","family":"Nollin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Borgers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Vanparijs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Van Den Bossche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000046175_ref016","first-page":"165","article-title":"Le mebendazole, un nouvel anthelmintique \u00e0 large spectre tr\u00e8s actif contre le trichocephale","volume":"66","author":"Vandepitte","year":"1973","journal-title":"Bulletin de la Soci\u00e9t\u00e9 de Pathologie exotique"},{"key":"S0031182000046175_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(73)90120-3"},{"key":"S0031182000046175_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-711050-9.50015-4"},{"key":"S0031182000046175_ref013","article-title":"Anthelmintic and histopathological effects of mebendazole on Trichinella spiralis in the rat","author":"Thienpont","year":"1973","journal-title":"Experimental Parasitology"},{"key":"S0031182000046175_ref012","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000045224"},{"key":"S0031182000046175_ref011","doi-asserted-by":"publisher","DOI":"10.1007\/BF00548649"},{"key":"S0031182000046175_ref002","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000078069"},{"key":"S0031182000046175_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(67)90079-3"},{"key":"S0031182000046175_ref017","unstructured":"Van Reempts J. & Borgers M. (1974). A simple polychrome stain for conventionally fixed, Epon-embedded tissues. (Submitted.)"},{"key":"S0031182000046175_ref005","doi-asserted-by":"publisher","DOI":"10.2307\/3278626"},{"key":"S0031182000046175_ref008","unstructured":"Gatti F. , Krubwa F. , Lontie M. , Vandepitte J. & Thienpont D. (1971). Congress on Tropical Pathology, Prague, 26 August, 1971."},{"key":"S0031182000046175_ref007","first-page":"275","article-title":"P32 incorporation into energetic phosphatases of the heart and skeletal muscles in rats infected with T. spiralis","volume":"13","author":"Garbuli\u0144ski","year":"1965","journal-title":"Acta Parasitologica Polonica"},{"key":"S0031182000046175_ref003","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1971.03190030039008"},{"key":"S0031182000046175_ref004","first-page":"843","article-title":"Therapeutic action of mebendazole against human helminthiasis","volume":"63","author":"Chaia","year":"1971","journal-title":"F\u00f4lha Medica"},{"key":"S0031182000046175_ref001","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1961.11686027"},{"key":"S0031182000046175_ref006","doi-asserted-by":"publisher","DOI":"10.1007\/BF00964791"},{"key":"S0031182000046175_ref009","first-page":"589","article-title":"Morphologic observations of Trichinella infected muscles in mice treated with Thiabendazole and Neguvon","volume":"12","author":"Kozar","year":"1966","journal-title":"Wiadomosci Parazytologiczne"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000046175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T17:05:29Z","timestamp":1559149529000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000046175\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,8]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1974,8]]}},"alternative-id":["S0031182000046175"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000046175","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,8]]}}}