{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T17:53:21Z","timestamp":1699638801507},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":12241,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1975,10]]},"abstract":"<jats:p>When adult <jats:italic>Nippostrongylus brasiliensis<\/jats:italic> were maintained <jats:italic>in vitro<\/jats:italic> they became damaged. Using the criteria of ultrastructural morphology, acetylcholinesterase isoenzyme pattern and the behaviour of the worms after transfer to a normal rat, this damage appeared to be similar to that produced by the <jats:italic>in vivo<\/jats:italic> action of antibodies.<\/jats:p><jats:p>Antibodies were shown to be responsible for the anterior migration of adult worms which occurs during primary infections in mature rats and in the prolonged infections seen in lactating and immature rats.<\/jats:p><jats:p>Antibody damaged worms and worms unaffected by antibodies were equally able to stimulate the immune response required for worm expulsion. Apparently antibody damage is not required for the initiation of the second immune component necessary for expulsion of this parasite.<\/jats:p>","DOI":"10.1017\/s0031182000046710","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T12:57:35Z","timestamp":1244206655000},"page":"275-283","source":"Crossref","is-referenced-by-count":19,"title":["<i>Nippostrongylus brasiliensis<\/i>: further properties of antibody-damaged worms and induction of comparable damage by maintaining worms <i>in vitro<\/i>"],"prefix":"10.1017","volume":"71","author":[{"given":"R. J.","family":"Love","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bridget M.","family":"Ogilvie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane J.","family":"McLaren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000046710_ref016","doi-asserted-by":"publisher","DOI":"10.2307\/3276634"},{"key":"S0031182000046710_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(74)90006-X"},{"key":"S0031182000046710_ref010","unstructured":"Love R. J. & Ogilvie B. M. (1975). Nippostrongylus brasiliensis in young rats: failure to induce expulsion of adult worm populations by lymphoid cells. Clinical and Experimental Immunology. 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(In the Press.)"},{"key":"S0031182000046710_ref001","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000068785"},{"key":"S0031182000046710_ref014","first-page":"94","article-title":"Immunity in the parasitic relationship between helminths and hosts","volume":"17","author":"Ogilvie","year":"1973","journal-title":"Progress in Allergy"},{"key":"S0031182000046710_ref015","first-page":"147","article-title":"Cooperation between antibodies and cells in immunity to a nematode parasite","volume":"19","author":"Ogilvie","year":"1974","journal-title":"Transplantation Review"},{"key":"S0031182000046710_ref005","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000071572"},{"key":"S0031182000046710_ref008","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000069808"},{"key":"S0031182000046710_ref007","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200004587X"},{"key":"S0031182000046710_ref004","first-page":"467","article-title":"Expulsion of Nippostrongylus brasiliensis from the intestine of rats: Collaboration between humoral and cellular components of the immune response","volume":"24","author":"Dineen","year":"1973","journal-title":"Immunology"},{"key":"S0031182000046710_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(74)90007-1"},{"key":"S0031182000046710_ref013","doi-asserted-by":"publisher","DOI":"10.2307\/3276966"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000046710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T15:12:34Z","timestamp":1559142754000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000046710\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,10]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1975,10]]}},"alternative-id":["S0031182000046710"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000046710","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,10]]}}}