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The proportion of mice unable to achieve worm expulsion (non-responders) was relatively constant in various populations of the strain but was increased by selective breeding from mice of known status. Crosses made between non-responder and responder mice produced progeny that were almost all (92%) of responder phenotype, showing that the ability to achieve worm expulsion was inherited as a dominant characteristic. It is suggested that the genetic control involves a small number of genes; the possible immunological mechanisms by which control is mediated are briefly discussed.<\/jats:p>","DOI":"10.1017\/s0031182000047156","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T16:57:35Z","timestamp":1244221055000},"page":"377-384","source":"Crossref","is-referenced-by-count":35,"title":["Genetic control of immune responses to parasites: selection for responsiveness and non-responsiveness to <i>Trichuris muris<\/i> in random-bred mice"],"prefix":"10.1017","volume":"71","author":[{"given":"D.","family":"Wakelin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000047156_ref019","doi-asserted-by":"publisher","DOI":"10.1084\/jem.57.5.793"},{"key":"S0031182000047156_ref021","first-page":"127","article-title":"The inheritance of resistance to trichostrongylidosis in sheep. 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