{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:32:35Z","timestamp":1762075955522},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":12180,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1975,12]]},"abstract":"<jats:p>Oncospheral agglutination given by sera immunized with <jats:italic>Hymenolepisnana<\/jats:italic> eggs is described as a new way of assessing <jats:italic>H. nana<\/jats:italic> infection. All sera of mice which possessed acquired protective immunity against reinfection by <jats:italic>H. nana<\/jats:italic> eggs had the potency to induce oncospheral agglutination <jats:italic>in vitro<\/jats:italic>. Only oncospheres, which had been hatched, agglutinated, no agglutination occurred in sera from uninfected mice. Oncospheral agglutination was carried out by mixing 0\u00b71 ml of serial two-fold dilutions of serum and 0\u00b71 ml of Hanks' balanced salt solution containing about 600 hatched oncospheres. Titre of agglutinins was indicated as a reciprocal of the final dilution capable of giving agglutination clusters made of three or more oncospheres. Agglutinins developed within 14 days after a primary infection with 500 shell-free eggs. There was no rapid increase of agglutinins within 4 days following a secondary infection. The titre increase coincided with the increase in dosages of eggs. Agglutinins were thought to be immunoglobulins, because the potency of the serum to agglutinate oncospheres was extinguished after absorption of globulins with rabbit anti-mouse globulin serum.<\/jats:p><jats:p>Agglutinins were produced in rabbits by intravenous injections of shell-free eggs. The titres of the rabbit sera were much higher than those of mouse sera.<\/jats:p>","DOI":"10.1017\/s0031182000047223","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T16:57:35Z","timestamp":1244221055000},"page":"465-473","source":"Crossref","is-referenced-by-count":15,"title":["<i>In vitro<\/i> oncospheral agglutination given by immune sera from mice infected, and rabbits injected, with eggs of <i>Hymenolepis nana<\/i>"],"prefix":"10.1017","volume":"71","author":[{"given":"Akira","family":"Ito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000047223_ref004","first-page":"210","article-title":"Studies on helminth immunity. IV. 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