{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:32:16Z","timestamp":1762075936126},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":11752,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1977,2]]},"abstract":"<jats:p>Wistar-Furth strain male rats and CFW strain male mice were immunized against <jats:italic>Trichinella spiralis<\/jats:italic> using an antegenic fraction derived from a cell-free homogenate of mature muscle larvae.<\/jats:p><jats:p>In rats, animlas immunized with 250 \u03bcg of antigen harboured singnificantly fewer (135000) muscle larvae 30 days after oral challenge than controls (231000). Furhter 7-day-old adult worms derived from immunized rats shed 48% fewer (P &lt; 0\u00b7001) newborn larvae over a 24 h period <jats:italic>in vitro<\/jats:italic> than adult worms from non-immunized animals.<\/jats:p><jats:p>Mice were injected with either 10 or 100 \u03bcg of antigen. In comparison with non-immunized controls, mice immunized with 100\u03bcg of antigen harboured significantly fewer adult worms at days 7 and 9 after oral challenge infection, while female worms recovered from immune mice on days 6\u201310 after challenge shed fewer newborn larvae <jats:italic>in vitro<\/jats:italic>. Finally, mice immunized with 100\u03bcg of antigen harboured significantly fewer (10391) muscle larvae at 30 days after challenge than did controls (47750).<\/jats:p><jats:p>Immunization of mice with 10\u03bc of antigen did not induce a statistically significant reduction in adult worms at either days 7 or 9 after challenge (P &lt; 0\u00b75). However, adult female worms from mice receiving 10\u03bcg of antigen still shed fewer larvae than did adults from control mice (P &lt; 0\u00b705). Mice immunized with 10\u03bcg of antigen harboured significantly fewer (13700) recoverable muscle larvae than did controls at 30 days after challenge (39000).<\/jats:p>","DOI":"10.1017\/s0031182000047570","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T16:55:26Z","timestamp":1244220926000},"page":"109-119","source":"Crossref","is-referenced-by-count":68,"title":["The <i>in vivo<\/i> and <i>in vitro<\/i> ananlysis of immunity to <i>Trichinella spiralis<\/i> in mice and rats"],"prefix":"10.1017","volume":"74","author":[{"given":"D. D.","family":"Despommier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. C.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. S.","family":"Blair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000047570_ref024","first-page":"963","volume-title":"Immunity to Parasitic Animals","volume":"2","author":"Otto","year":"1970"},{"key":"S0031182000047570_ref021","first-page":"484","article-title":"Immunity of rats to reinfection with Trichinella spiralis","volume":"14","author":"McCoy","year":"1931","journal-title":"American Journal of Hygine"},{"key":"S0031182000047570_ref020","first-page":"7","article-title":"The immune mechanism which exples the intestinal stage of Trichinella spiralis from rats","volume":"30","author":"Love","year":"1976","journal-title":"Immunology"},{"key":"S0031182000047570_ref018","first-page":"119","article-title":"Protective immunity to Nippostrongylus brasiliensis in the rat. III. 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