{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T19:00:33Z","timestamp":1774897233029,"version":"3.50.1"},"reference-count":12,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":11571,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1977,8]]},"abstract":"<jats:p>Primary immune expulsion of <jats:italic>Trichuris muris<\/jats:italic> was markedly delayed by concurrent infection with <jats:italic>Nematospiroides dubius<\/jats:italic>. Maximum delay of expulsion was dependent on size and timing of <jats:italic>N. dubius<\/jats:italic> infection relative to <jats:italic>T. muris<\/jats:italic> infection. In NIH mice infection with 400 <jats:italic>N. dubius<\/jats:italic> larvae immediately before or after <jats:italic>T. muris<\/jats:italic> infection was found to be most effective in suppressing expulsion. Infection on day 8 of <jats:italic>T. muris<\/jats:italic> infection, when mice are sensitized to <jats:italic>T. muris<\/jats:italic>, also impaired expulsion. From this evidence it is suggested that the larvae of <jats:italic>N. dubius<\/jats:italic> are immunosuppressive and that the efferent role of the immune response to <jats:italic>T. muris<\/jats:italic> is inhibited. The results are discussed in terms of non-specific immunosuppression and their relevance to the tropical disease situation is emphasized.<\/jats:p>","DOI":"10.1017\/s0031182000048332","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T08:04:37Z","timestamp":1244189077000},"page":"71-78","source":"Crossref","is-referenced-by-count":108,"title":["Impairment of primary expulsion of <i>Trichuris muris<\/i> in mice concurrently infected with <i>Nematospiroides dubius<\/i>"],"prefix":"10.1017","volume":"75","author":[{"given":"Simon N","family":"Jenkins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerzy M","family":"Behnke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000048332_ref005","doi-asserted-by":"publisher","DOI":"10.2307\/3278613"},{"key":"S0031182000048332_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(72)90007-0"},{"key":"S0031182000048332_ref006","doi-asserted-by":"publisher","DOI":"10.2307\/3273905"},{"key":"S0031182000048332_ref010","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000072395"},{"key":"S0031182000048332_ref002","doi-asserted-by":"publisher","DOI":"10.2307\/3279091"},{"key":"S0031182000048332_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00026535"},{"key":"S0031182000048332_ref001","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1972.11686804"},{"key":"S0031182000048332_ref008","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000046783"},{"key":"S0031182000048332_ref011","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000053142"},{"key":"S0031182000048332_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(75)90028-4"},{"key":"S0031182000048332_ref007","first-page":"485","article-title":"Depression of plaque forming cells to SRBC by the new-born larvae of Trichinella spiralis","volume":"30","author":"Faubert","year":"1976","journal-title":"Immunology"},{"key":"S0031182000048332_ref012","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000048472"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000048332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T17:20:11Z","timestamp":1558977611000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000048332\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,8]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,8]]}},"alternative-id":["S0031182000048332"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000048332","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,8]]}}}