{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T17:26:56Z","timestamp":1750440416880},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":11571,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1977,8]]},"abstract":"<jats:p>High primary doses of<jats:italic>Trichinella spiralis<\/jats:italic>administered orally to Kenyan baboons (<jats:italic>Papio anubis<\/jats:italic>) induced a marked but unpredictable eosinophilia which started 2\u20133 weeks after infection and persisted as erratic waves for at least 6 months. Low primary oral doses induced no eosinophilia but a later, high challenge gave an accelerated eosino-philic response, although the peak was lower than in high primary infection. Intravenous injection of infective<jats:italic>T. spiralis<\/jats:italic>larvae resulted in a predictable, rapid eosinophilic response which persisted for several weeks. Intravenous injection of a particulate material, Sepharose, gave no oesinophilic response.<\/jats:p><jats:p>Percutaneous<jats:italic>Schistosoma mansoni<\/jats:italic>infection of baboons resulted in a two-stage eosinophilic response: an initial rise occurred about \u2154 of the way through the pre-patent period and was followed by a second rise at the onset of patency. After peaking, the eosinophilia waned erratically over the next 3 or 4 weeks.<\/jats:p><jats:p>A strong antibody response, measured by countercurrent imnruno-electrophoresis, was given in oral infections with<jats:italic>T. spiralis<\/jats:italic>, but intravenous injections elicited little or no antibody formation. Parasitological evidence indicated no cross-resistance to<jats:italic>S. mansoni<\/jats:italic>in baboons injected with<jats:italic>T. spiralis<\/jats:italic>9 days previously. Thus, the intravenous injection of infective<jats:italic>T. spiralis<\/jats:italic>larvae appears to be a suitable method of inducing experimentally a non-specific eosinophilia to investigate possible immune mechanisms to<jats:italic>S. mansoni<\/jats:italic>in the baboon.<\/jats:p>","DOI":"10.1017\/s0031182000048356","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T12:04:37Z","timestamp":1244203477000},"page":"89-100","source":"Crossref","is-referenced-by-count":6,"title":["Eosinophilia in Kenyan baboons (<i>Papio anubis<\/i>) induced by<i>Trichinella spiralis<\/i>and<i>Schistosoma mansoni<\/i>"],"prefix":"10.1017","volume":"75","author":[{"given":"R. F.","family":"Sturrock","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. E.","family":"Butterworth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. D.","family":"Karamsadkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Kimani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Imbuga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Houba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000048356_ref020","first-page":"553","article-title":"The immunology of schistosomiasis","volume":"51","year":"1974","journal-title":"Bulletin of the World Health Organization"},{"key":"S0031182000048356_ref019","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200004693X"},{"key":"S0031182000048356_ref018","volume-title":"Statistical Methods","author":"Snedecor","year":"1967"},{"key":"S0031182000048356_ref016","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00019921"},{"key":"S0031182000048356_ref012","first-page":"222","volume-title":"Trichinosis in Man and Animals","author":"Kagan","year":"1970"},{"key":"S0031182000048356_ref009","first-page":"190","volume-title":"Trichinosis in Man and Animals","author":"Gould","year":"1970"},{"key":"S0031182000048356_ref008","first-page":"33","article-title":"Studies on schistosomiasis. II. Egg formation in Schistosoma mansoni and the fate of the egg in the host","volume":"6","author":"G\u00f6nnert","year":"1955","journal-title":"Zeitschrift f\u00fcr Tropenmedizin und Parasitologie"},{"key":"S0031182000048356_ref006","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1976.25.299"},{"key":"S0031182000048356_ref003","doi-asserted-by":"publisher","DOI":"10.1038\/256727a0"},{"key":"S0031182000048356_ref001","doi-asserted-by":"publisher","DOI":"10.1084\/jem.131.6.1271"},{"key":"S0031182000048356_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(65)90037-8"},{"key":"S0031182000048356_ref007","doi-asserted-by":"publisher","DOI":"10.2307\/3272948"},{"key":"S0031182000048356_ref010","doi-asserted-by":"crossref","first-page":"705","DOI":"10.4049\/jimmunol.117.2.705","article-title":"Soluble antigens and antibodies in sera from baboons infected with Schistosoma mansoni","volume":"117","author":"Houba","year":"1976","journal-title":"Journal of Immunology"},{"key":"S0031182000048356_ref013","first-page":"29","article-title":"Ueber Eosinophile in Schweineblut bei trichinose","volume":"129","author":"Maass","year":"1933","journal-title":"Zentralblatt f\u00fcr Bacteriologie"},{"key":"S0031182000048356_ref017","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.4049\/jimmunol.114.4.1348","article-title":"Induction of blood eosinophilia by pulmonary embolization of antigen-coated, particles: the relationship to cell-mediated immunity","volume":"114","author":"Schriber","year":"1975","journal-title":"Journal of Immunology"},{"key":"S0031182000048356_ref014","doi-asserted-by":"publisher","DOI":"10.1084\/jem.142.4.805"},{"key":"S0031182000048356_ref015","first-page":"629","article-title":"The distribution of Trichinella spiralis larvae in the muscles of primates","volume":"8","author":"Nelson","year":"1962","journal-title":"Wiadomo\u015bci Parazytologiczne"},{"key":"S0031182000048356_ref005","first-page":"653","article-title":"Schistosomiasis: an experimental model for the study of immunopathologic mechanisms which involve eosinophils","volume":"12","author":"Colley","year":"1973","journal-title":"Advances in the Biosciences"},{"key":"S0031182000048356_ref011","first-page":"51","volume-title":"The Baboon in Medical Research","volume":"2","author":"Hummer","year":"1967"},{"key":"S0031182000048356_ref002","doi-asserted-by":"publisher","DOI":"10.1159\/000231610"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000048356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T14:19:40Z","timestamp":1685024380000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000048356\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,8]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,8]]}},"alternative-id":["S0031182000048356"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000048356","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,8]]}}}