{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:39:50Z","timestamp":1782823190938,"version":"3.54.5"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":8771,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1985,4]]},"abstract":"<jats:p>Genetic differences in mice influence both the pathological and immunological responses to schistosomiasis mansoni. We have investigated the nature of the genetic factors influencing these responses by crossing two different pairs of strains of mice which vary in their response to infection, and measuring responses in the F<jats:sub>1<\/jats:sub>hybrid and backcross offspring. The two pairs of parental strains differed with respect to faecal egg excretion, accumulation of eggs in the tissues, splenomegaly and pattern of antibody response. The numbers of adult worms which establish do not differ between strains. The inheritance of the responses measured was different in the two pairs of strains. The F<jats:sub>1<\/jats:sub>hybrid from the C57BL\/6\/Ol\/a \/c cross resembled the low-responding parental strain (CBA\/Ca) with respect to faecal egg excretion, accumulation of eggs in the tissues and splenomegaly, and was intermediate in its pattern of antibody response. The F<jats:sub>1<\/jats:sub>hybrid mice from the NIH \/Ca cross resembled the high-responding strain (CBA\/Ca) with respect to faecal egg excretion, accumulation of eggs in the tissues and splenomegaly, and had an earlier and greater antibody response than either parental strain. No evidence of single gene influence on any of these responses was seen in the backcross offspring. The differing patterns of inheritance and the absence of a bimodal distribution of responses in the backcross offspring indicate that each of these responses is influenced by multiple genes. The pattern of antibody response did not correlate between strains with any of the pathological res The positive correlation of egg accumulation in the tissues and faecal egg excretion suggests that there are genetic influences on the fecundity of the worms.<\/jats:p>","DOI":"10.1017\/s003118200005099x","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T11:50:42Z","timestamp":1244202642000},"page":"289-300","source":"Crossref","is-referenced-by-count":6,"title":["The inheritance of responses to schistosomiasis mansoni in two pairs of inbred strains of mice"],"prefix":"10.1017","volume":"90","author":[{"given":"Janet T.","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R.","family":"Kusel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S003118200005099X_ref013","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000057139"},{"key":"S003118200005099X_ref002","first-page":"4","article-title":"Greater resistance to development of severe schistosomiasis in Brazilian Negroes","volume":"50","author":"Bina","year":"1978","journal-title":"Human Biology"},{"key":"S003118200005099X_ref008","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/144.2.148"},{"key":"S003118200005099X_ref014","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1128\/IAI.32.1.260-267.1981","article-title":"Strain differences in lymphocyte responses an. in vitro suppressor cell induction between Schistosoma mansoni-infected C57BL\/6 and CBA mice","volume":"32","author":"Lewis","year":"1981","journal-title":"Infection and Immunity"},{"key":"S003118200005099X_ref018","first-page":"954","article-title":"Two distinctive patterns of monocyte immunoregulatory and effector functions in heavy human infections wit","volume":"131","author":"Olds","year":"1983","journal-title":"Schistosoma mansoni. 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Variation in macrophage schistosomulacidal and tumoricidal activities among mouse strains and correlation with resistance to reinfection","volume":"131","author":"James","year":"1983","journal-title":"Journal of Immunology"},{"key":"S003118200005099X_ref004","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.1979.tb00342.x"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S003118200005099X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T14:01:06Z","timestamp":1685023266000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S003118200005099X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,4]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1985,4]]}},"alternative-id":["S003118200005099X"],"URL":"https:\/\/doi.org\/10.1017\/s003118200005099x","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,4]]}}}