{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:29:08Z","timestamp":1770748148379,"version":"3.49.0"},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":8771,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1985,4]]},"abstract":"<jats:p>Significant levels of resistance against<jats:italic>Schistosoma mansoai<\/jats:italic>challenge were developed by mice exposed to highly irradiated (20 krad.) cercariae of the homologous species (53\u201367%), whereas vaccination with<jats:italic>S. bovis, S. haematobiurn<\/jats:italic>or<jats:italic>S.japonicuni<\/jats:italic>failed to confer significant levels of resistance (\u20135\u201312%), thus confirming the specificity ofthe immunizing procedure. Attempts to transfer resistance to naive recipients by injection of serum and of spleen or lymph node cells from donor mice vaccinated with highly irradiated cercariae were largely unsuccessful. However, significant levels of resistance could be transferred to mice by injection of serum from rabbits exposed to irradiated cercariae. Comparable levels of resistance were conferred by injection of serum at the time of challenge (34\u201369%) or 5\u20136 days later (31\u201356%). Tn contrast, sera from rabbits injected with solubleegg antigen or homogenized cercariae failed to confer protection upon recipient mice. Sera from vaccinated mice, vaccinated rabbits and antigen-injected rabbits all caused cell adherence to skin-transformed schistosomula hut neither the level of adherence nor the serum titre correlated with the ability to confer protection to mice.<\/jats:p>","DOI":"10.1017\/s0031182000051003","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T11:50:42Z","timestamp":1244202642000},"page":"301-312","source":"Crossref","is-referenced-by-count":60,"title":["Resistance against<i>Schistosoma mansoni<\/i>induced by highly irradiated infections: studies on species specificity of immunization and attempts to transfer resistance"],"prefix":"10.1017","volume":"90","author":[{"given":"Q. D.","family":"Bickle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. J.","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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M. (1983). Studies on the host\u2013parasite relationship of Schistosoma bovis in the mouse. Ph.D. thesis, University of London."},{"key":"S0031182000051003_ref022","first-page":"291","article-title":"Vaccination in schistosomiasis","volume":"72","author":"Taylor","year":"1977","journal-title":"Les coiloque l'institut national de la sant\u00e9 et de la recherche m\u00e9dicale"},{"key":"S0031182000051003_ref004","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000049234"},{"key":"S0031182000051003_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000053294"},{"key":"S0031182000051003_ref019","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.4049\/jimmunol.128.4.1880","article-title":"Mechanisms of protective immunity against Schistosoma mansoni infection in mice vaccinated with irradiated cercariae","volume":"128","author":"Sher","year":"1982","journal-title":"Journal of Immunology"},{"key":"S0031182000051003_ref008","first-page":"205","article-title":"The mitotic activity of, and antibody production by, sensitized lymphocytes quantified aftertransfer into irradiated recipients","volume":"31","author":"Doenhoff","year":"1976","journal-title":"Immunology"},{"key":"S0031182000051003_ref009","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000049222"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000051003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T14:01:12Z","timestamp":1685023272000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000051003\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,4]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1985,4]]}},"alternative-id":["S0031182000051003"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000051003","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,4]]}}}