{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:01:05Z","timestamp":1788562865969,"version":"build-2803163510"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":11936,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1976,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Hamsters (WO strain) with a primary infection of <jats:italic>Schistosoma mansoni<\/jats:italic> or <jats:italic>S. haematobium<\/jats:italic> rapidly developed immunity to homologous challenge judged by the lung recovery assay. Immunity was detected at 4\u20135 weeks and reached a plateau 6 weeks after infection.<\/jats:p><jats:p>Using this information, hamsters with an 8-week primary infection with <jats:italic>S. mansoni<\/jats:italic> or <jats:italic>S. haematobium<\/jats:italic> were tested for resistance to homologous reinfection and resistance to a challenge with the other species of schistosome. Primary infection with <jats:italic>S. mansoni<\/jats:italic> or <jats:italic>S. haematobium<\/jats:italic> conferred a high level of immunity to reinfection with either species of schistosome judged by the perfusion assay, involving recovery of adult worms 6\u201310 weeks following challenge. Estimation of the level of immunity with the lung recovery assay, 5 days after challenge, indicated that immunity due to a primary infection with <jats:italic>S.mansoni<\/jats:italic> acted at or before migration of the challenge through the lungs but immunity stimulated by a primary <jats:italic>S. haematobium<\/jats:italic> infection was only partially effective at the lung stage and substantial destruction of challenging organisms occurred at a later stage of development.<\/jats:p><jats:p>Antibodies in immune sera of hamsters with a primary <jats:italic>S. mansoni<\/jats:italic> or <jats:italic>S. haematobium<\/jats:italic> infection were shown to bind to common antigens on the surface of young schistosomula of either species by u.v. microscopy using as detecting agent a fluorescein-labelled rabbit antiserum directed against hamster globulins.<\/jats:p>","DOI":"10.1017\/s0031182000051325","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T12:05:56Z","timestamp":1244203556000},"page":"53-64","source":"Crossref","is-referenced-by-count":23,"title":["Cross-immunity to <i>Schistosoma mansoni<\/i> and <i>S. haematobium<\/i> in the hamster"],"prefix":"10.1017","volume":"73","author":[{"given":"M. A.","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Clegg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Webbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000051325_ref027","doi-asserted-by":"publisher","DOI":"10.1007\/BF01932479"},{"key":"S0031182000051325_ref021","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/130.6.626"},{"key":"S0031182000051325_ref017","unstructured":"Perez H. A. (1974). Investigation on the mechanism of protective immunity to Schistosoma mansoni in the laboratory rat. Ph.D. Thesis, Brunei University, Uxbridge."},{"key":"S0031182000051325_ref005","first-page":"1","article-title":"The influence of acquired resistance in the epidemiology of bilharziasis","volume":"12","author":"Clarke","year":"1966","journal-title":"Central African Journal of Medicine"},{"key":"S0031182000051325_ref010","first-page":"101","volume-title":"Fluorescent Antibody Methods","author":"Goldman","year":"1968"},{"key":"S0031182000051325_ref004","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/1966412123"},{"key":"S0031182000051325_ref002","doi-asserted-by":"publisher","DOI":"10.1038\/253474a0"},{"key":"S0031182000051325_ref023","first-page":"357","article-title":"Partial isolation of a membrane antigen which induces the formation of antibodies lethal to schistosomes cultured in vitro","volume":"18","author":"Sher","year":"1974","journal-title":"Clinical Experimental Parasitology"},{"key":"S0031182000051325_ref013","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000048873"},{"key":"S0031182000051325_ref016","first-page":"9","article-title":"Studies on heterologous immunity in schistosomiasis. 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Heterologous schistosome immunity in mice","volume":"38","author":"Nelson","year":"1968","journal-title":"Bulletin of the World Health Organization"},{"key":"S0031182000051325_ref015","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1975.24.955"},{"key":"S0031182000051325_ref008","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1975.24.74"},{"key":"S0031182000051325_ref014","doi-asserted-by":"publisher","DOI":"10.2307\/3273883"},{"key":"S0031182000051325_ref028","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000086248"},{"key":"S0031182000051325_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(72)90036-7"},{"key":"S0031182000051325_ref022","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000052124"},{"key":"S0031182000051325_ref019","first-page":"587","article-title":"Studies on heterologous schistosoma immunity in sheep","volume":"47","author":"Preston","year":"1972","journal-title":"Bulletin of the World Health Organization"},{"key":"S0031182000051325_ref011","unstructured":"Mahmoud A. A. F. , Warren K. S. & Peters P. A. (1975). The r\u00f4le of eosinophils in acquired resistance to Schistosoma mansoni infection in mice. In International Conference on Schistosomiasis, Cairo, Egypt, October 1975, pp. 179\u201381."},{"key":"S0031182000051325_ref009","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1974.23.420"},{"key":"S0031182000051325_ref018","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000063046"},{"key":"S0031182000051325_ref020","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(66)90268-9"},{"key":"S0031182000051325_ref007","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197007000-00027"},{"key":"S0031182000051325_ref001","doi-asserted-by":"publisher","DOI":"10.1038\/252503a0"},{"key":"S0031182000051325_ref025","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(74)90255-7"},{"key":"S0031182000051325_ref026","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1976.11687100"},{"key":"S0031182000051325_ref029","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(67)90160-5"},{"key":"S0031182000051325_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(74)90026-5"},{"key":"S0031182000051325_ref024","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000051313"},{"key":"S0031182000051325_ref012","first-page":"591","article-title":"Studies on heterologous immunity in schistosomiasis. 6. 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