{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T11:49:56Z","timestamp":1772279396623,"version":"3.50.1"},"reference-count":35,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":10841,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1979,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The freeze fracture technique has been used to study the internal cyto-architecture of the surface membranes of the parasite and erythrocyte in<jats:italic>Plasmodium knowlesi<\/jats:italic>infections. Six fracture faces, derived from the plasma membrane and 2 pellicular membranes, have been identified at the surface of the free merozoite. The apposed leaflets of the 2 pellicular membranes show the characteristic features of E fracture faces, a result compatible with the view that the pellicular membranes line a potential cisterna. There is evidence to suggest that there may be changes in the distribution and density of the integral proteins in the merozoite plasma membrane at invasion. Furthermore, vesicles consisting of stacked membranes occur within and around the erythrocyte invagination at invasion; it is suggested that these vesicles are released from the merozoite rhoptries. Formation of the parasitophorous vacuole is accompanied by dramatic changes in the density and distribution of intra-membraneous particles (IMP) in the vacuolar membrane. Initially there is a great reduction in particle numbers, but subsequently the particles reappear and show reversed polarity. The possible causes and implications of these changes are discussed. The intra-erythrocytic parasite synthesizes new transmembrane proteins as development proceeds, and the trophozoite and schizont stages of development are characterized by the appearance of circular, particle-free regions in the parasite plasmalemma. There is a decrease in the density of transmembrane proteins in the erythrocyte plasma membrane during parasite maturation, and the P face IMP show the characteristic features of aggregation.<\/jats:p>","DOI":"10.1017\/s0031182000052021","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T16:51:29Z","timestamp":1244220689000},"page":"125-139","source":"Crossref","is-referenced-by-count":73,"title":["Freeze fracture studies on the interaction between the malaria parasite and the host erythrocyte in<i>Plasmodium knowlesi infections<\/i>"],"prefix":"10.1017","volume":"79","author":[{"given":"Diane J.","family":"McLaren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. H.","family":"Bannister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. I.","family":"Trigg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. A.","family":"Butcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000052021_ref035","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(76)90200-5"},{"key":"S0031182000052021_ref030","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(74)90071-6"},{"key":"S0031182000052021_ref027","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.67.2.310"},{"key":"S0031182000052021_ref026","first-page":"149","article-title":"Morphologic studies on the freeze-etched avian malaria parasite Plasmodium gallinaceum","volume":"39","author":"Mezoely","year":"1972","journal-title":"Proceedings of the Helminthological Society of Washington"},{"key":"S0031182000052021_ref025","first-page":"199","article-title":"A freeze-fracture study on the parasite\/erythrocyte interrelationship in Plasmodium knowlesi infections","volume":"55","author":"McLaren","year":"1977","journal-title":"Bulletin of the World Health Organization"},{"key":"S0031182000052021_ref023","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.72.2.242"},{"key":"S0031182000052021_ref022","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.74.2.501"},{"key":"S0031182000052021_ref020","doi-asserted-by":"publisher","DOI":"10.2307\/3277308"},{"key":"S0031182000052021_ref019","first-page":"9","article-title":"Babesia sp. the relationship of stage of development to structure of intra- and extracellular parasites","volume":"26","author":"Kreier","year":"1975","journal-title":"Tropenmedizin und Parasitologie"},{"key":"S0031182000052021_ref018","first-page":"191","article-title":"A histidine-rich protein from Plasmodium falciparum and its interaction with membranes","volume":"55","author":"Kilejian","year":"1977","journal-title":"Bulletin of the World Health Organization"},{"key":"S0031182000052021_ref014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1977.tb01017.x"},{"key":"S0031182000052021_ref012","doi-asserted-by":"publisher","DOI":"10.2307\/3277307"},{"key":"S0031182000052021_ref010","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000047235"},{"key":"S0031182000052021_ref009","doi-asserted-by":"publisher","DOI":"10.1126\/science.1166299"},{"key":"S0031182000052021_ref008","first-page":"163","article-title":"Recent advances in understanding the invasion of erythrocytes by merozoites of Plasmodium knowlesi","volume":"55","author":"Bannister","year":"1977","journal-title":"Bulletin of the World Health Organization"},{"key":"S0031182000052021_ref006","unstructured":"Bannister L. H. (1977). The invasion of red cells by Plasmodium. Symposium of the British Society for Parasitology 15, (ed. Taylor A. E. 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