{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T06:43:22Z","timestamp":1708929802781},"reference-count":11,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":9380,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1983,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The anthelmintic effect of an alcoholic extract from a shrub, <jats:italic>Diospyros mollis<\/jats:italic>, popularly known as Ma-Klua in Thailand, on the adults and larvae of the dwarf tapeworm, <jats:italic>Hymenolepis nana<\/jats:italic>, in mice was studied in comparison with that of flubendazole. The experimentally infected mice were given a single oral dose of 10\u20131000 mg of Ma-Klua extract or flu-bendazole\/kg body wt 1, 2, 3, 4, or 12 days post-infection and autopsied 14 days post-infection. Ma-Klua extract was effective in the elimination of adults (ED<jats:sub>50<\/jats:sub> = 79 mg\/kg) but not larvae. Drastic effects of Ma-Klua extract on the motility and structure of adults were observed and the number of the adults in mice decreased with time after administration of the drug 12 days post-infection. The small numbers of adults remaining in the host intestine 2 days after the drug administration showed severe damage in the gravid segments. These facts were thought to be responsible for the significant reduction in egg output observed 1 and 2 days after medication. Fresh eggs exposed to Ma-Klua extract <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>, or <jats:italic>in vivo<\/jats:italic> alone showed reduced infectivity. The effect of flubendazole on adults and larvae was minimal.<\/jats:p>","DOI":"10.1017\/s0031182000052458","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T16:32:24Z","timestamp":1244219544000},"page":"103-111","source":"Crossref","is-referenced-by-count":6,"title":["Effects of alcoholic extract from Ma-Klua (<i>Diospyros mollis<\/i>) on adults and larvae of the dwarf tapeworm, <i>Hymenolepis nana<\/i> in mice and on the infectivity of the eggs"],"prefix":"10.1017","volume":"87","author":[{"given":"Jun","family":"Maki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asami","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Yanagisawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000052458_ref001","doi-asserted-by":"publisher","DOI":"10.2307\/3276089"},{"key":"S0031182000052458_ref002","first-page":"414","article-title":"Studies on the life history and host\u2013parasite relations of Hymenolepis fraterna (H. nana, var.fraterna, Stilles) in white mice","volume":"22","author":"Hunninen","year":"1935","journal-title":"American Journal of Hygiene"},{"key":"S0031182000052458_ref009","first-page":"2000","article-title":"Anthelmintic efficacy of diospyrol and its derivatives","volume":"24","author":"Sen","year":"1974","journal-title":"Arzneimittel-Forschung"},{"key":"S0031182000052458_ref006","first-page":"103","article-title":"On the infectivity of eggs in the rectum of mice infected with Hymenolepis nana","volume":"29","author":"Maki","year":"1980","journal-title":"Japanese Journal of Parasitology"},{"key":"S0031182000052458_ref004","unstructured":"Kobayashi A. , Hara T. , Unhanand M. , Srinophakun S. , Seedonrusmi T. , Jeradit C. & Vajrasthira S. (1979). Anthelmintic effects of Ma-Klua against Ascaris and hookworm infections. Abstracts of the 21st Meeting of the Japanese Society for Tropical Medicine and Hygiene, Tokyo p. 47."},{"key":"S0031182000052458_ref010","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1981.30.135"},{"key":"S0031182000052458_ref008","doi-asserted-by":"publisher","DOI":"10.2307\/3274255"},{"key":"S0031182000052458_ref011","first-page":"605","article-title":"Biological and pharmacological properties of flubendazole","volume":"28","author":"Thienpont","year":"1978","journal-title":"Arzneimittel-Forschung"},{"key":"S0031182000052458_ref003","first-page":"15","article-title":"On the effects of flubendazole against helminths","volume":"30","author":"Kagel","year":"1981","journal-title":"Japanese Journal of Parasitology"},{"key":"S0031182000052458_ref005","first-page":"121","article-title":"Anthelmintic activity of the fruits of Diospyros mollis and tests for activity of other persimmons","volume":"24","author":"Luttermoser","year":"1957","journal-title":"Proceedings of the Helminthological Society of Washington"},{"key":"S0031182000052458_ref007","volume-title":"Anthelmintic Effects of Diospyros mollis Extract in Man and Dog","author":"Mokkhasmit","year":"1967"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000052458","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T22:43:49Z","timestamp":1558651429000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000052458\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,8]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,8]]}},"alternative-id":["S0031182000052458"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000052458","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,8]]}}}