{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:10:01Z","timestamp":1739146201157,"version":"3.37.0"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":8100,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1987,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Anti-thymocyte serum (ATS) was administered to CD-1 mice infected with 100<jats:italic>Trichinella spiralis<\/jats:italic>larvae and its effects on intestinal lysophospholipase (EC 3.1.1.5) activity, peripheral blood lymphocytes and bone marrow, peripheral blood and intestinal eosinophilia were assayed in the same experimental animal. The ATS caused a significant suppression of both the tissue lysophospholipase response and eosinophilia, in all three compartments, when compared to the values found in infected mice that were either treated with normal rabbit serum (NRS) or untreated. The suppressed eosinophil response and reduced lysophospholipase activity demonstrated a close temporal relation throughout the experiment. These findings support the hypothesis that helminth parasite-induced eosinophilia is the cause of increased lysophospholipase activity present in parasitized tissue and that the responses are thymus cell dependent.<\/jats:p>","DOI":"10.1017\/s0031182000053506","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T16:16:38Z","timestamp":1244218598000},"page":"115-122","source":"Crossref","is-referenced-by-count":3,"title":["Effects of anti-thymocyte serum on the eosinophil and lysophospholipase responses in mice infected with<i>Trichinella spiralis<\/i>"],"prefix":"10.1017","volume":"94","author":[{"given":"K.","family":"Adewusi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Goven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000053506_ref011","doi-asserted-by":"crossref","first-page":"355","DOI":"10.4049\/jimmunol.124.1.355","article-title":"Host defense mechanisms against Trichinella spiralis infection in the mouse: Eosinophil-mediated destruction of newborn larvae in vitro","volume":"124","author":"Kazura","year":"1980","journal-title":"Journal of Immunology"},{"key":"S0031182000053506_ref016","doi-asserted-by":"publisher","DOI":"10.2307\/3281018"},{"key":"S0031182000053506_ref005","first-page":"243","volume-title":"Advances in Host Defense Mechanisms","volume":"1","author":"Dessein","year":"1982"},{"key":"S0031182000053506_ref023","doi-asserted-by":"publisher","DOI":"10.2307\/3277722"},{"key":"S0031182000053506_ref010","doi-asserted-by":"publisher","DOI":"10.1007\/BF00925517"},{"key":"S0031182000053506_ref021","doi-asserted-by":"publisher","DOI":"10.1177\/14.12.907"},{"key":"S0031182000053506_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(74)90069-1"},{"key":"S0031182000053506_ref017","first-page":"385","article-title":"Basophils and eosinophils in three strains of rats and in athymic (nude) rats following infection with the nematode Nippostrongylus brasiliensis or Trichinella spiralis","volume":"39","author":"Ogilvie","year":"1980","journal-title":"Immunology"},{"key":"S0031182000053506_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(75)90075-2"},{"key":"S0031182000053506_ref013","doi-asserted-by":"publisher","DOI":"10.2307\/3273385"},{"key":"S0031182000053506_ref004","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-133-34584"},{"key":"S0031182000053506_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(79)90028-6"},{"key":"S0031182000053506_ref001","first-page":"269","volume-title":"Advances in Host Defense Mechanisms","volume":"1","author":"Ackerman","year":"1982"},{"volume-title":"Basic Medical Laboratory Technology","year":"1975","author":"Kirk","key":"S0031182000053506_ref012"},{"key":"S0031182000053506_ref002","doi-asserted-by":"publisher","DOI":"10.2307\/3277345"},{"key":"S0031182000053506_ref006","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1981.30.350"},{"key":"S0031182000053506_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(79)90085-7"},{"key":"S0031182000053506_ref009","doi-asserted-by":"publisher","DOI":"10.2307\/3281281"},{"key":"S0031182000053506_ref018","doi-asserted-by":"publisher","DOI":"10.1007\/BF02531719"},{"key":"S0031182000053506_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(75)90042-9"},{"key":"S0031182000053506_ref020","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1128\/IAI.15.1.13-18.1977","article-title":"Angiostrongylus cantonensis: Phospholipase in nonsensitized and sensitized rats after challenge","volume":"15","author":"Ottolenghi","year":"1977","journal-title":"Infection and Immunity"},{"key":"S0031182000053506_ref022","first-page":"581","article-title":"Trichinella spiralis infection in congenitally athymic (nude) mice. Parasitology, serological and haematological studies with observations in intestinal pathology","volume":"33","author":"Ruitenburg","year":"1977","journal-title":"Immunology"},{"key":"S0031182000053506_ref024","first-page":"339","volume-title":"Advances in Immunology","volume":"27","author":"Weller","year":"1979"},{"key":"S0031182000053506_ref025","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(84)90028-6"},{"key":"S0031182000053506_ref003","first-page":"293","volume-title":"The Eosinophil in Health and Disease","author":"Colley","year":"1980"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000053506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T23:29:15Z","timestamp":1739143755000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000053506\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,2]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,2]]}},"alternative-id":["S0031182000053506"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000053506","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"type":"print","value":"0031-1820"},{"type":"electronic","value":"1469-8161"}],"subject":[],"published":{"date-parts":[[1987,2]]}}}