{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:10:07Z","timestamp":1739146207777,"version":"3.37.0"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":8100,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1987,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The effects of the phenothiazine, Stelazine, on<jats:italic>Hymenolepis diminuta<\/jats:italic>were investigated. The cestode was incubated for 10 min at 37 \u00b0C with 1 mM trifluoperazine, in the presence and absence of Ca<jats:sup>2+<\/jats:sup>. Assay of brush border enzymes showed that drug treatment lowered the activities of alkaline phosphatase, Ca<jats:sup>2+<\/jats:sup>-ATP'ase, 5\u2032-nucleotidase and type 1 phosphodiesterase. This occurred in parallel with a significant reduction in tegumental protein. Under these conditions gross changes in ultrastructural appearance and cellular organization were observed. There was a lack of ordered microtriches and the distal cytoplasm was absent. Glycogen granules were scattered throughout the cytoplasm within the subtegumental layer. The connective tissue also appeared to be in some disarray. The effects of Stelazine appeared to be dependent on time and were significantly increased when Ca<jats:sup>2+<\/jats:sup>was included in the incubation medium. Incubation with the less hydrophobic phenothiazine trifluoperazine sulphoxide had minimal effect on the integrity of the cestode. The results reported here support the premise that certain phenothiazines may be considered as potential cestocidal agents.<\/jats:p>","DOI":"10.1017\/s003118200005352x","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T16:16:38Z","timestamp":1244218598000},"page":"135-149","source":"Crossref","is-referenced-by-count":3,"title":["Biochemical and ultrastructural investigation of the effect of Stelazine (trifluoperazine) on<i>Hymenolepis diminuta<\/i>(Cestoda)"],"prefix":"10.1017","volume":"94","author":[{"given":"Jayne B.","family":"Hipkiss","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Skinner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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B. , Branford White C. J. & Peters T. J. (1986). Effect of phenothiazines on Hymenolepis diminuta and on its Ca2+-dependent ATPase. Molecular and Biochemical Parasitology (in the Press)."},{"key":"S003118200005352X_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(84)90113-0"},{"key":"S003118200005352X_ref021","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1972.tb01456.x"},{"key":"S003118200005352X_ref001","first-page":"1","volume-title":"Biochemistry of Parasites","author":"Barrett","year":"1981"},{"key":"S003118200005352X_ref014","first-page":"581","article-title":"Mechanism by which psychotropic drugs inhibit adenosine cyclic 3\u2032, 5\u2032 monophosphate phosphodiesterase of brain","volume":"12","author":"Levin","year":"1976","journal-title":"Molecular Pharmacology"},{"key":"S003118200005352X_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(80)90134-3"},{"key":"S003118200005352X_ref003","doi-asserted-by":"publisher","DOI":"10.1007\/BF00927373"},{"key":"S003118200005352X_ref004","doi-asserted-by":"publisher","DOI":"10.1007\/BF00928338"},{"key":"S003118200005352X_ref016","first-page":"391","article-title":"A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples","volume":"140","author":"Markwell","year":"1978","journal-title":"Analytical Biochemistry"},{"key":"S003118200005352X_ref017","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1982.62.1.1"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S003118200005352X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T23:29:16Z","timestamp":1739143756000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S003118200005352X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,2]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,2]]}},"alternative-id":["S003118200005352X"],"URL":"https:\/\/doi.org\/10.1017\/s003118200005352x","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"type":"print","value":"0031-1820"},{"type":"electronic","value":"1469-8161"}],"subject":[],"published":{"date-parts":[[1987,2]]}}}