{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:48:57Z","timestamp":1762271337059},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":10719,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1979,12]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Antigenic relationships of 4 stocks of<jats:italic>Trypanosoma congolense<\/jats:italic>from different parts of Africa were examined by immunofluorescence (IFAT) and neutralization tests. Antisera to each stock were obtained from rabbits infected with trypanosomes transmitted by<jats:italic>Glossina morsitans<\/jats:italic>. Trypanosomes for use as antigens were obtained from local skin reactions developing on rabbits infected with 2 of the stocks. Using the IFAT and antisera at end-point dilutions approximately 40% of the trypanosomes fluoresced strongly and a further 30% less intensely with homologous antisera, indicating antigenic heterogeneity among the trypanosomes developing in the skin. Using antisera at low dilutions some samples gave cross-reactions with trypanosomes of heterologous stocks, but at higher dilutions there were no cross-reactions with either of the antigens. The lack of cross-reactions at high antiserum dilutions was interpreted as indicating antigenic differences between the 4 trypanosome stocks. Using neutralization tests only homologous antisera reduced the infectivity of trypanosome suspensions. Overall, these observations indicated that there were at least 3 different strains of<jats:italic>T. congolense<\/jats:italic>among the 4 stocks examined.<\/jats:p>","DOI":"10.1017\/s0031182000053749","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T16:50:54Z","timestamp":1244220654000},"page":"337-347","source":"Crossref","is-referenced-by-count":10,"title":["Observations on the antigenicity and serological relationships of stocks of<i>Trypanosoma congolense<\/i>from East and West Africa"],"prefix":"10.1017","volume":"79","author":[{"given":"A. G.","family":"Luckins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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Differenziersungsmethod von trypanosomenstammen","volume":"36","author":"Schilling","year":"1932","journal-title":"Archiv f\u00fcr Schiffs und Tropenhygiene"},{"key":"S0031182000053749_ref010","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1017\/S0007485300028352","article-title":"The trypanosome infections of tsetse flies in Northern Nigeria and a new method of estimation","volume":"13","author":"Lloyd","year":"1924","journal-title":"Bulletin of Entomological Research"},{"key":"S0031182000053749_ref005","first-page":"403","article-title":"Antigenic variation in trypanosomes with particular reference to Trypanosoma gambiense","volume":"57","author":"Gray","year":"1977","journal-title":"Annales de la Soci\u00e9t\u00e9 belge de M\u00e9decine tropicale"},{"key":"S0031182000053749_ref001","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1977.tb00987.x"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000053749","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T07:21:38Z","timestamp":1589872898000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000053749\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,12]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1979,12]]}},"alternative-id":["S0031182000053749"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000053749","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,12]]}}}