{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T16:50:44Z","timestamp":1761929444286},"reference-count":49,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":10719,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1979,12]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Administration of the immunostimulants<jats:italic>Corynebacterium parvum, Bacillus Calmette-Gu\u00e9rin<\/jats:italic>(BCG) or<jats:italic>Bordetella pertussis<\/jats:italic>prior to, or at the same time as, challenge with<jats:italic>Trypanosoma congolense<\/jats:italic>significantly increased survival times in mice, both of trypano-susceptible (A\/J) and trypano-resistant (C57Bl) strains. The increased survival time was associated with significant alterations in parasitaemia, which included lengthening of the pre-patent period, a delay in the time taken to reach the first peak of parasitaemia and a reduction in the level of parasitaemia. Similar results were obtained when these strains of mice were challenged with<jats:italic>Trypanosoma brucei<\/jats:italic>following pre-treatment with<jats:italic>C. parvum<\/jats:italic>. Thus, by the use of immunostimulants it was possible to reduce the susceptibility of mice to trypanosomiasis and the hope is that this can also be achieved with domestic livestock.<\/jats:p>","DOI":"10.1017\/s0031182000053750","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T16:50:54Z","timestamp":1244220654000},"page":"349-366","source":"Crossref","is-referenced-by-count":31,"title":["Non-specific induction of increased resistance in mice to<i>Trypanosoma congolense<\/i>and<i>Trypanosoma brucei<\/i>by immunostimulants"],"prefix":"10.1017","volume":"79","author":[{"given":"Max","family":"Murray","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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