{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:49:12Z","timestamp":1762271352924},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":10719,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1979,12]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p><jats:italic>In vitro<\/jats:italic>excretory\/secretory products of 4-week (immature) and 8- week-old (mature)<jats:italic>Fasciola hepatica<\/jats:italic>parasites, derived from rats, were injected together with adjuvant into naive rats and mice. Resistance to infection was assessed in rats by counting adults in the bile ducts at 9 weeks, or in mice by recording deaths after oral challenge with a high dose of viable metacercariae. Exposure of rats to excretory\/secretory products of immature<jats:italic>F. hepatica<\/jats:italic>conferred a significant degree of resistance which was comparable to the level of resistance induced following oral administration of a low number of metacercariae. No protection against infection was seen in rats injected with excretory\/secretory products from mature, bile duct-derived worms. In mice, no obvious mouse strain variation in susceptibility to first infection existed and hypothymic nude mice were as susceptible to infection as intact mice. As determined by protection against death, vaccination with excretory\/secretory products derived from immature<jats:italic>P. hepatica<\/jats:italic>was without effect in mice. It is concluded that \u2018host protective antigens\u2019, at least for rats, were present in the excretory\/secretory products of immature<jats:italic>F. hepatica<\/jats:italic>larvae.<\/jats:p>","DOI":"10.1017\/s0031182000053786","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T16:50:54Z","timestamp":1244220654000},"page":"393-400","source":"Crossref","is-referenced-by-count":36,"title":["<i>Fasciola hepatica<\/i>: attempts to induce protection against infection in rats and mice by injection of excretory\/secretory products of immature worms"],"prefix":"10.1017","volume":"79","author":[{"given":"G. R.","family":"Rajasekariah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. F.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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