{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:40:55Z","timestamp":1792597255910,"version":"4.5.0"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":8041,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1987,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>\n                    The long-term,\n                    <jats:italic>in vivo<\/jats:italic>\n                    effects of a single, subcurative dose (200 mg\/kg body weight of mouse) of praziquantel on the structure of adult\n                    <jats:italic>Schistosoma mansoni<\/jats:italic>\n                    and on the process and speed of tegumental repair are described. In both male and female worms praziquantel caused often extensive damage to the tegument, in the form of surface blebbings, swellings and lesions, and vacuolization and disruption of the subtegumental tissues. Repair of the drug-induced tegumental damage occurred slowly with partial and, more rarely, complete repair only being seen after 65 days post-treatment (p.t.), although signs of damage were still observed, particularly in male worms, at 100 days p.t. In contrast, repair of damage to the subtegumental\/parenchymal tissues including the tegumental perikarya occurred relatively quickly, with the majority of worms examined appearing normal by 8\u201312 days p.t. The possible role(s) of the host immune response in relation to the speed of tegumental repair\n                    <jats:italic>in vivo<\/jats:italic>\n                    is discussed.\n                  <\/jats:p>","DOI":"10.1017\/s0031182000053920","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T07:42:39Z","timestamp":1244187759000},"page":"243-254","source":"Crossref","is-referenced-by-count":65,"title":["<i>Schistosoma mansoni<\/i>\n                    : structural damage and tegumental repair after\n                    <i>in vivo<\/i>\n                    treatment with praziquantel"],"prefix":"10.1017","volume":"94","author":[{"given":"M. K.","family":"Shaw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A.","family":"Erasmus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000053920_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60188-8"},{"key":"S0031182000053920_ref004","doi-asserted-by":"publisher","DOI":"10.1007\/BF00927527"},{"key":"S0031182000053920_ref003","doi-asserted-by":"publisher","DOI":"10.2307\/3280390"},{"key":"S0031182000053920_ref001","unstructured":"Andrews P. (1978). Effects of praziquantel on the metabolism of Schistosoma mansoni. Fourth International Congress of Parasitology, Warsaw. Section D, 5\u20136."},{"key":"S0031182000053920_ref023","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(82)90097-2"},{"key":"S0031182000053920_ref026","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(80)90026-0"},{"key":"S0031182000053920_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(84)90045-6"},{"key":"S0031182000053920_ref013","volume-title":"Tropical Medicine Research Studies 1","author":"McLaren","year":"1980"},{"key":"S0031182000053920_ref007","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000056808"},{"key":"S0031182000053920_ref005","doi-asserted-by":"publisher","DOI":"10.2307\/3281098"},{"key":"S0031182000053920_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(84)90042-0"},{"key":"S0031182000053920_ref024","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000086248"},{"key":"S0031182000053920_ref020","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(85)90041-4"},{"key":"S0031182000053920_ref008","first-page":"232","article-title":"The immune-dependence of schistosomicidal chemotherapy: Relative lack of efficacy of an antimonal in Schistosoma mansoni-infected mice deprived of their T-cells and the demonstration of drug-antiserum synergy","volume":"33","author":"Doenhoff","year":"1978","journal-title":"Clinical and Experimental Immunology"},{"key":"S0031182000053920_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(73)90046-5"},{"key":"S0031182000053920_ref002","first-page":"538","article-title":"A summary of the efficacy of praziquantel against schistosomes in animal experiments and notes on its mode of action","volume":"31","author":"Andrews","year":"1981","journal-title":"Arzneimittel-Forschung\/Drug Research"},{"key":"S0031182000053920_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(84)90025-2"},{"key":"S0031182000053920_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/0040-8166(85)90016-3"},{"key":"S0031182000053920_ref022","doi-asserted-by":"publisher","DOI":"10.1007\/BF00926674"},{"key":"S0031182000053920_ref025","doi-asserted-by":"publisher","DOI":"10.1002\/9780470719312.ch14"},{"key":"S0031182000053920_ref027","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000045777"},{"key":"S0031182000053920_ref028","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000047533"},{"key":"S0031182000053920_ref014","first-page":"544","article-title":"In vivo and in vitro experiments on the effects of praziquantel on Schistosoma mansoni","volume":"31","author":"Mehlhorn","year":"1981","journal-title":"Arzneimittel-Forschung\/Drug Research"},{"key":"S0031182000053920_ref021","doi-asserted-by":"publisher","DOI":"10.1007\/BF00934012"},{"key":"S0031182000053920_ref015","first-page":"229","article-title":"Light and electron microscopic studies on Schistosoma mansoni granulomas of mice livers following treatment with praziquantel","volume":"33","author":"Mehlhorn","year":"1982","journal-title":"Tropenmedizin und Parasitologie"},{"key":"S0031182000053920_ref009","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1967.16.483"},{"key":"S0031182000053920_ref006","doi-asserted-by":"publisher","DOI":"10.2307\/3281229"},{"key":"S0031182000053920_ref011","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000046709"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000053920","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T17:59:46Z","timestamp":1558461586000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000053920\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,4]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987,4]]}},"alternative-id":["S0031182000053920"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000053920","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,4]]}}}