{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T14:11:43Z","timestamp":1685023903550},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":8041,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1987,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Two isolates of<jats:italic>Schistosoma mansoni<\/jats:italic>from Puerto Rico and Egypt were examined to determine if there were differences in surface antigens of the schistosomulum and to assess the ability of the two isolates to induce protection against one another<jats:italic>in vivo<\/jats:italic>. Immune mouse and human patient antisera recognized the same antigens on the schistosomulum surface of both isolates. However, mice immunized with schistosomula-released products from the Egyptian isolate recognized an additional antigen of<jats:italic>M<\/jats:italic><jats:sub>r<\/jats:sub>13K on the Egyptian schistosomulum surface which was not present in the Puerto Rican isolate. In quantitative radioimmunoassay, sera from mice vaccinated with irradiated Egyptian cercariae bound more strongly to Egyptian schistosomula than to Puerto Rican parasites. Both isolates cross-protected against each other, but mice were less immune to challenge with Egyptian cercariae after being immunized with Puerto Rican irradiated cercariae. There was no difference in immunity to challenge when Egyptian irradiated cercariae were used to immunize. Although this evidence suggested some heterogeneity within the Egyptian isolate, cloned cercariae of the Egyptian isolate did not vary in their ability to cross-protect against each other. Furthermore, antisera from mice immunized with clones of Egyptian cercariae recognized the same schistosomulum surface antigens. The results reported here indicate that although there were small differences between the two isolates the major surface antigens are conserved.<\/jats:p>","DOI":"10.1017\/s0031182000053968","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T11:42:39Z","timestamp":1244202159000},"page":"301-312","source":"Crossref","is-referenced-by-count":6,"title":["Surface antigens of and cross-protection between two geographical isolates of<i>Schistosoma mansoni<\/i>"],"prefix":"10.1017","volume":"94","author":[{"given":"F.","family":"Hackett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J. G.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Omer-Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. R.","family":"Smithers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000053968_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(84)90274-8"},{"key":"S0031182000053968_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(73)90111-2"},{"key":"S0031182000053968_ref008","first-page":"295","article-title":"Comparison of geographical strains of Schistosoma mansoni in the rhesus monkey","volume":"46","author":"Powers","year":"1972","journal-title":"Bulletin of the World Health Organization"},{"key":"S0031182000053968_ref007","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.137.11.3601","article-title":"A major role for carbohydrate epitopes preferentially recognized by chronically infected mice in the determination of Schistosoma mansoni schistosomula surface antigenicity","author":"Omer-Ali","year":"1986","journal-title":"Journal of Immunology"},{"key":"S0031182000053968_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(85)90347-5"},{"key":"S0031182000053968_ref005","first-page":"147","article-title":"Influence of parasite strain on chemotherapy of murine infections with Schistosoma mansoni","volume":"45","author":"Lee","year":"1971","journal-title":"Bulletin of the World Health Organization"},{"key":"S0031182000053968_ref004","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/j.1460-2075.1984.tb01786.x","article-title":"Cell free synthesis of Schistosoma mansoni surface antigens: stage specificity of their expression","volume":"3","author":"Knight","year":"1984","journal-title":"Journal of the European Molecular Biology Organisation"},{"key":"S0031182000053968_ref016","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000086248"},{"key":"S0031182000053968_ref012","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1128\/IAI.41.2.591-597.1983","article-title":"Identification of surface antigens of schistosomula of Schistosoma mansoni recognized by antibodies from mice immunized by chronic infection and by exposure to highly irradiated cercariae","volume":"41","author":"Simpson","year":"1983","journal-title":"Infection and Immunity"},{"key":"S0031182000053968_ref003","first-page":"S83","volume-title":"Parasites and Molecular Biology: Applications of New Techniques. Symposia of the British Society for Parasitology","volume":"23","author":"Kemp","year":"1986"},{"key":"S0031182000053968_ref014","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000051179"},{"key":"S0031182000053968_ref013","first-page":"205","volume-title":"Current Topics in Microbiology and Immunology","volume":"120","author":"Simpson","year":"1985"},{"key":"S0031182000053968_ref011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1985.tb00065.x"},{"key":"S0031182000053968_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(85)90034-7"},{"key":"S0031182000053968_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(74)90076-9"},{"key":"S0031182000053968_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(78)91322-0"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000053968","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T13:53:22Z","timestamp":1685022802000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000053968\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,4]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987,4]]}},"alternative-id":["S0031182000053968"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000053968","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,4]]}}}