{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:06:02Z","timestamp":1758632762674},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":8041,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1987,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Immunity to<jats:italic>Schistosoma mansoni<\/jats:italic>was investigated in congenitally athymic (Nu\/Nu) rats, irradiated rats and in mast cell-depleted rats. Nu\/Nu rats failed to develop significant resistance following vaccination with irradiated cercariae, although Nu\/Nu recipients of serum from vaccinated Fischer rats (VRS) manifested resistance comparable to heterozygous controls, suggesting that T-cells were required in the induction of resistance but were not involved in the efferent arm of antibody-dependent elimination. Radiosensitive cells (including eosinophils, basophils, neutrophils, lymphocytes and mast cells) were apparently not essential for the antibody-dependent elimination of lung or post-lung stages since irradiated (700\u2013750 rad.) recipients of VRS manifested comparable degrees of resistance to unirradiated controls in spite of a greater than 85% reduction in total blood leucocyte counts after irradiation. Depletion of 99 % of tissue mast cells by treatment of rats with Compound 48\/80 had no significant effect on the attrition of a challenge infection in rats rendered immune by vaccination with irradiated cercariae or by transfer of VRS. However, there was a significant increase in worm recovery in unimmunized and mast cell-depleted or irradiated rats, indicating that mast cells and perhaps other radio-isotope sensitive cells may be involved in innate resistance.<\/jats:p>","DOI":"10.1017\/s003118200005397x","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T11:42:39Z","timestamp":1244202159000},"page":"313-326","source":"Crossref","is-referenced-by-count":18,"title":["Immunity to<i>Schistosoma mansoni<\/i>in congenitally athymic, irradiated and mast cell-depleted rats"],"prefix":"10.1017","volume":"94","author":[{"given":"M. J.","family":"Ford","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q. 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