{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T21:45:04Z","timestamp":1763329504692},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":8041,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1987,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Previous workers have reported that significant resistance to<jats:italic>Schistosoma mansoni<\/jats:italic>cercarial challenge can be induced in mice by immunization with various<jats:italic>Fasciola hepatica<\/jats:italic>antigen preparations. We have attempted to reproduce these observations and have also carried out similar experiments in rats. In our hands, however, CBA mice did not develop either antibodies against the schistosomular surface, or significant resistance to challenge after immunization with heterologous antigens. Similar results were obtained in Fischer rats, but rats did develop significant resistance after immunization with homologous (schistosomular) antigens, even without adjuvant, and the homologous \u2018protective\u2019 antigens could be separated by antibody-affinity chromatography using serum from rats vaccinated with irradiated cercariae. Thus, we found no evidence for the existence of shared \u2018protective\u2019 antigens between<jats:italic>S. mansoni<\/jats:italic>and<jats:italic>F. hepatica<\/jats:italic>, and suggest that this is further evidence that where heterologous resistance can be demonstrated between these two parasites, it is probably due to immunologically non-specific mechanisms.<\/jats:p>","DOI":"10.1017\/s0031182000053981","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T11:42:39Z","timestamp":1244202159000},"page":"327-336","source":"Crossref","is-referenced-by-count":6,"title":["Reevaluation of the potential of<i>Fasciola hepatica<\/i>antigens for immunization against<i>Schistosoma mansoni<\/i>infection"],"prefix":"10.1017","volume":"94","author":[{"given":"M. J.","family":"Ford","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. G.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q. D.","family":"Bickle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000053981_ref019","volume-title":"Parasite Antigens in Protection, Diagnosis and Escape","author":"Simpson","year":"1986"},{"key":"S0031182000053981_ref017","volume-title":"Practical Immunology.","author":"Hudson","year":"1976"},{"key":"S0031182000053981_ref014","first-page":"381","article-title":"A new approach to the study of immunity to schistosomiasis","volume":"67","author":"Hillyer","year":"1975","journal-title":"Bolet\u00edn de la Asociaci\u00f3n M\u00e9dica de Puerto Rico"},{"key":"S0031182000053981_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(77)90092-3"},{"key":"S0031182000053981_ref011","doi-asserted-by":"publisher","DOI":"10.2307\/3280456"},{"key":"S0031182000053981_ref009","first-page":"2568","article-title":"Can we vaccinate against schistosomes?","volume":"35","author":"Hillyer","year":"1976","journal-title":"Federation Proceedings"},{"key":"S0031182000053981_ref008","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000053452"},{"key":"S0031182000053981_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(83)90002-4"},{"key":"S0031182000053981_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000053294"},{"key":"S0031182000053981_ref004","first-page":"121","article-title":"Structure antigeniques des helminths. Aspects immunologiques des relations h\u00f4te-parasite","volume":"16","author":"Capron","year":"1968","journal-title":"Pathologie Biologie"},{"key":"S0031182000053981_ref002","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1986.tb00836.x"},{"key":"S0031182000053981_ref001","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.4049\/jimmunol.128.5.2101","article-title":"Studies on the surface antigenicity and susceptibility to antibody-dependent killing of developing schistosomula using sera from chronically infected mice and mice vaccinated with irradiated cercariae","volume":"128","author":"Bickle","year":"1982","journal-title":"Journal of Immunology"},{"key":"S0031182000053981_ref006","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000001347"},{"key":"S0031182000053981_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(78)90273-9"},{"key":"S0031182000053981_ref020","volume-title":"Immunology of Parasite Infections","author":"Smithers","year":"1982"},{"key":"S0031182000053981_ref015","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1128\/IAI.26.3.802-807.1979","article-title":"Immunity in Schistosoma mansoni using antigens of Fasciola hepatica isolated by concanavalin A affinity chromatography","volume":"26","author":"Hillyer","year":"1979","journal-title":"Infection and Immunity"},{"key":"S0031182000053981_ref007","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000056705"},{"key":"S0031182000053981_ref018","first-page":"312","article-title":"Further studies in mice regarding a possible vaccine against bilharziasis","volume":"68","author":"Reyes","year":"1976","journal-title":"Bolet\u00edn de la Asociaci\u00f3n M\u00e9dica de Puerto Rico"},{"key":"S0031182000053981_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(79)90111-5"},{"key":"S0031182000053981_ref016","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/145.2.728"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000053981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T07:04:02Z","timestamp":1710399842000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000053981\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,4]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987,4]]}},"alternative-id":["S0031182000053981"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000053981","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,4]]}}}