{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:42:36Z","timestamp":1759333356912},"reference-count":11,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":10475,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1980,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>A novel tetrahydroquinolinyl ester, quinfamide, administered orally in multiple doses for 3 days had an ED<jats:sub>50<\/jats:sub>, of 0\u00b725 mg\/kg\/day (total dose 0\u00b775 mg\/kg) for eradicating <jats:italic>Entamoeba criceti<\/jats:italic> in hamsters in several tests. It was significantly more active by direct comparison than 3 commercially available amoebicides and at least as active as 2 other esters of the parent compound, 1-(dichloroacetyl)-1,2,3,4-tetrahydro-6-quinonnol. After administration of a single dose, ED<jats:sub>50<\/jats:sub>, calculations for quinfamide averaged 0\u00b79 mg\/kg. Quinfamide was considerably more active than the other tetrahydroquinolinols, diloxanide furoate and teclozan, and it was approximately 1\u00b75 times more active than etofamide; a statistical significance between the latter 2 drugs could be demonstrated in one of 4 tests. Administered prophylactically, quinfamide was shown to protect hamsters from re-infection with <jats:italic>E. criceti<\/jats:italic>. It also inhibited propagation of <jats:italic>E. histolytica<\/jats:italic> in vitro at a concentration of 20 \/tg\/ml. No adverse effects were noted in rodents after a single dose as high as 10 g\/kg. Daily administration to monkeys of doses up to 500 mg\/kg for as long as 37 days produced no pharmacological aberrations during or after medication; haematological studies and urine analyses were normal and no gross or microscopical tissue changes attributable to quinfamide were observed. No toxicity was revealed following acute (2 g\/kg) and chronic (500 mg\/kg\/day \u00d7 31 days) administration of the drug to dogs and rats, respectively.<\/jats:p>","DOI":"10.1017\/s0031182000055128","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T12:47:37Z","timestamp":1244206057000},"page":"157-168","source":"Crossref","is-referenced-by-count":9,"title":["Activity of quinfamide against natural infections of <i>Entamoeba criceti<\/i> in hamsters: a new potent agent for intestinal amoebiasis"],"prefix":"10.1017","volume":"81","author":[{"given":"R. G.","family":"Slighter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Yarinsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. P.","family":"Drobeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000055128_ref008","first-page":"296","article-title":"Tratamento da amebiase intestinal em 24 horas com novo esquema posologico do teclosan","volume":"69","author":"Fernandes","year":"1974","journal-title":"A Folha Medica"},{"key":"S0031182000055128_ref006","first-page":"554","article-title":"Chemotherapeutic properties of Win 5047 (Mantomide). A new synthetic amebicide","volume":"4","author":"Dennis","year":"1954","journal-title":"Antibiotics and Chemotherapy"},{"key":"S0031182000055128_ref002","doi-asserted-by":"publisher","DOI":"10.1021\/jm00191a031"},{"key":"S0031182000055128_ref004","first-page":"245","article-title":"in vitro and in vivo amebicidal activity of N, N\u2032-bis(dichloroacetyl)diamines","volume":"11","author":"Berberian","year":"1961","journal-title":"Antibiotics and Chemotherapy"},{"key":"S0031182000055128_ref001","first-page":"137","article-title":"Clinical laboratory trials with teclozan (Falmonox) in mild cases of amebiasis","volume":"48","author":"Arcilla-latonio","year":"1972","journal-title":"Journal of the Philippine Medical Association"},{"key":"S0031182000055128_ref007","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1949.s1-29.683"},{"key":"S0031182000055128_ref003","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1961.10.503"},{"key":"S0031182000055128_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4832-5662-7.50010-6"},{"key":"S0031182000055128_ref009","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-57-14776"},{"key":"S0031182000055128_ref010","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1972.tb03512.x"},{"key":"S0031182000055128_ref011","first-page":"454","article-title":"Teclozan:N, N\u2032-bis(dichloroacetyl)-N, N\u2032-bis(2-ethoxvethyl)-1,4-xylylenediamine","volume":"14","author":"Surrey","year":"1978","journal-title":"Drugs of Today"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000055128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T17:43:21Z","timestamp":1558806201000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000055128\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,8]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1980,8]]}},"alternative-id":["S0031182000055128"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000055128","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,8]]}}}