{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T04:16:23Z","timestamp":1648700183815},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":7980,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1987,6]]},"abstract":"<jats:p>Using foot-pad infection of female C57BL\/6, DBA\/2J and NMRI-IVIC mice as an animal model for American cutaneous leishmaniasis (ACL), we evaluated the inhibitory effect of Formycin B (FoB) on the infection produced by 7 different <jats:italic>Leishmania<\/jats:italic> isolates. When treatment was initiated some days, or even some weeks, after infection a significant leishmanistatic effect was detected on mice infected with all <jats:italic>Leishmania<\/jats:italic> isolates, which reached 30\u201355 weeks for some isolates. The optimal dose schedule was 1\u00b725 mg\/kg body weight\/day, injected intraperitoneally for 20 consecutive days. Significant differences in the sensitivity of various <jats:italic>Leishmania<\/jats:italic> spp. to FoB were found, either <jats:italic>in vivo<\/jats:italic>, or <jats:italic>in vitro<\/jats:italic> where a high [<jats:sup>3<\/jats:sup>H]FoB incorporation rate was found only for certain <jats:italic>Leishmania<\/jats:italic> isolates. The low toxicity of this drug and the sensitivity of the 7 <jats:italic>Leishmania<\/jats:italic> isolates tested suggest that FoB could be useful in the treatment of ACL.<\/jats:p>","DOI":"10.1017\/s0031182000055815","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T12:16:22Z","timestamp":1244204182000},"page":"467-474","source":"Crossref","is-referenced-by-count":3,"title":["American <i>Leishmania<\/i> spp: Formycin B treatment of cutaneous leishmaniasis in mice"],"prefix":"10.1017","volume":"94","author":[{"given":"Tamara","family":"Rojas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Avila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000055815_ref013","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.1.288"},{"key":"S0031182000055815_ref011","doi-asserted-by":"publisher","DOI":"10.3109\/08820138009065998"},{"key":"S0031182000055815_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(83)90185-2"},{"key":"S0031182000055815_ref009","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.21.5"},{"key":"S0031182000055815_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(81)91976-8"},{"key":"S0031182000055815_ref002","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.22.3.380"},{"key":"S0031182000055815_ref004","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/151.4.698"},{"key":"S0031182000055815_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(83)90065-6"},{"key":"S0031182000055815_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(84)90197-7"},{"key":"S0031182000055815_ref016","unstructured":"World Health Organization (1983). Document TDR\/PR-6\/83.7-Leish., pp. 193\u2013205."},{"key":"S0031182000055815_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(81)90533-5"},{"key":"S0031182000055815_ref015","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1980.11687348"},{"key":"S0031182000055815_ref001","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1982.31.53"},{"key":"S0031182000055815_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(79)90062-6"},{"key":"S0031182000055815_ref003","first-page":"285","article-title":"Action of pyrazolopyrimidine derivatives on American Leishmania spp. promastigotes","volume":"83","author":"Avila","year":"1986","journal-title":"Comparative Biochemistry and Physiology"},{"key":"S0031182000055815_ref007","first-page":"144","article-title":"Isolation and purification of Leishmania brasiliensis amastigotes: its application to the comparative study of cell surface properties of amastigotes and promastigotes, NR stock","volume":"33","author":"Coello","year":"1982","journal-title":"Acta Cientifica Venezolana"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000055815","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T15:29:12Z","timestamp":1558452552000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000055815\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,6]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1987,6]]}},"alternative-id":["S0031182000055815"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000055815","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,6]]}}}