{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:20:34Z","timestamp":1776270034440,"version":"3.50.1"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":9561,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1983,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The immunogenicity of the secretory exo-antigen (EXA) originating in the stichosome of <jats:italic>Trichuris muris<\/jats:italic> has been investigated. High levels of immunity to challenge were produced using EXA (100 \u03bcg) by subcutaneous administration. Vaccination with a range of doses of EXA in Freunds' Incomplete Adjuvant (FIA) showed a dose response; 1 \u03bcg of EXA reduced the worm burden by 50% and doses of 10 \u03bcg or more reduced the worm burden by 80\u201390% at Day 9 post-infection. Worms recovered from vaccinated mice were significantly smaller than those from controls. A precipitin line identifiable with EXA was shown to immunize mice against <jats:italic>T. muris<\/jats:italic> challenge by vaccination. The protective antigen contained in EXA has been partially isolated using gel filtration, ion exchange filtration and isoelectric focusing and has been shown to be a protein of 30000 molecular weight having a pi of 6\u00b78\u20137\u00b73.<\/jats:p>","DOI":"10.1017\/s0031182000057188","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T12:36:26Z","timestamp":1244205386000},"page":"73-82","source":"Crossref","is-referenced-by-count":26,"title":["Functional antigens of <i>Trichuris muris<\/i> released during <i>in vitro<\/i> maintenance: their immunogenicity and partial purification"],"prefix":"10.1017","volume":"86","author":[{"given":"S. N.","family":"Jenkins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Wakelin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000057188_ref015","volume-title":"Biometry","author":"Sokal","year":"1969"},{"key":"S0031182000057188_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(75)90013-2"},{"key":"S0031182000057188_ref011","doi-asserted-by":"publisher","DOI":"10.1038\/287538a0"},{"key":"S0031182000057188_ref007","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000047648"},{"key":"S0031182000057188_ref006","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000048332"},{"key":"S0031182000057188_ref005","doi-asserted-by":"publisher","DOI":"10.2307\/3278960"},{"key":"S0031182000057188_ref010","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/51.5.1669"},{"key":"S0031182000057188_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(81)90116-8"},{"key":"S0031182000057188_ref002","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000047570"},{"key":"S0031182000057188_ref004","first-page":"76","article-title":"Functional antigens of Trichinella spiralis","volume":"56","author":"Despommier","year":"1970","journal-title":"Journal of Parasitology"},{"key":"S0031182000057188_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(76)90150-2"},{"key":"S0031182000057188_ref012","first-page":"59","volume-title":"Trichinellosis","author":"Phillip","year":"1981"},{"key":"S0031182000057188_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(73)90061-1"},{"key":"S0031182000057188_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60574-6"},{"key":"S0031182000057188_ref009","doi-asserted-by":"publisher","DOI":"10.1084\/jem.146.1.118"},{"key":"S0031182000057188_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(79)90079-1"},{"key":"S0031182000057188_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(65)90060-3"},{"key":"S0031182000057188_ref017","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000072395"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000057188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T15:39:21Z","timestamp":1558712361000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000057188\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,2]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,2]]}},"alternative-id":["S0031182000057188"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000057188","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,2]]}}}